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Short-Term Cd8+ T Cell Depletion Results In Blunted Liver Inflammation In Old Mice, Konner J. Terrebonne, David J. Buckley, Blessy Joseph, Sunita Sharma, Daniel W. Trott

International Journal of Exercise Science: Conference Proceedings

Advanced age is associated with an increase in basal inflammation of the organs. Previously we have found that T cells accumulate in the liver of old mice. A large proportion of these cells are CD8+ and produce inflammatory cytokines. We have previously demonstrated that CD8+ T cell depletion results in improved glucose tolerance in old mice. However, the mechanisms by which CD8+ depletion improves glucose tolerance is unclear. Therefore, we sought to determine whether pharmacologic CD8+ depletion would result in decreased liver specific inflammation in old mice compared to their old CD8+ intact counterparts. PURPOSE: To test the hypothesis …