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Full-Text Articles in Medicine and Health Sciences
Macrophage Response To Damage In Old And Young Skeletal Muscle, Jack Mehling, Robert D. Hyldahl, Mohadeseh Ahmadi
Macrophage Response To Damage In Old And Young Skeletal Muscle, Jack Mehling, Robert D. Hyldahl, Mohadeseh Ahmadi
International Journal of Exercise Science: Conference Proceedings
PURPOSE: In skeletal muscle, macrophages migrate to damaged fibers, influencing the inflammatory response during muscle regeneration. Macrophages experience polarization, exhibiting different phenotypes described as M1 (pro-inflammatory) and M2 (anti-inflammatory.) Failure to properly transition between phenotypes inhibits fiber regeneration. Previous animal literature suggests that dysregulated macrophage polarization may contribute to the decreased regenerative capacity of aging muscle. The purpose of this study is to quantify macrophage response and polarization in a model of muscle damage and regeneration in older humans. We hypothesized that older people would have a higher percentage of M2 macrophages relative to the young. METHODS: Seven …
Are Age-Related Differences In Critical Power And Work-Prime Simply Due To Differences In Muscle Mass, Abigail Dorff
Are Age-Related Differences In Critical Power And Work-Prime Simply Due To Differences In Muscle Mass, Abigail Dorff
International Journal of Exercise Science: Conference Proceedings
Critical Power (CP) represents the threshold between sustainable, steady-state and unsustainable, non-steady-state exercise while Work Prime (W’) represents tolerable work above CP. The combination of CP and W’ potently influence exercise tolerance. We recently observed age-related reductions in both CP and W’ in active adults. Age-related decreases in muscle mass, which was not measured, could account for the reduction in CP and W’. PURPOSE: The aim of this study was to determine if CP and W’ are decreased in active, older adults when normalizing for muscle mass. METHODS: Single leg knee extension exercise was used to determine CP …