Medicine and Health Sciences Commons^™

A Single Bout Of Vigorous Intensity Exercise Enhances The Efficacy Of Rituximab Against Human Chronic Lymphocytic Leukaemia B-Cells Ex Vivo, Harrison D. Collier-Bain, Annabelle Emery, Adam J. Causer, Frankie F. Brown, Rebecca Oliver, David Dutton, Josephine Crowe, Daniel Augustine, John Graby, Shoji Leach, Rachel Eddy, Daniela Rothschild-Rodriguez, Juliet C. Gray, Mark S. Cragg, Kirstie L. Cleary, Sally Moore, James Murray, James E. Turner, John P. Campbell

Research outputs 2022 to 2026

Chronic lymphocytic leukaemia (CLL) is characterised by the clonal proliferation and accumulation of mature B-cells and is often treated with rituximab, an anti-CD20 monoclonal antibody immunotherapy. Rituximab often fails to induce stringent disease eradication, due in part to failure of antibody-dependent cellular cytotoxicity (ADCC) which relies on natural killer (NK)-cells binding to rituximab-bound CD20 on B-cells. CLL cells are diffusely spread across lymphoid and other bodily tissues, and ADCC resistance in survival niches may be due to several factors including low NK-cell frequency and a suppressive stromal environment that promotes CLL cell survival. It is well established that exercise bouts …

Validity Of Apple Watch, Garmin Forerunner® 935 And Geneactiv For Estimating Energy Expenditure During Close Quarter Battle Training In Special Forces Soldiers, Angela Uphill, Kristina L. Kendall, Alison Fogarty, Stuart Guppy, Hannah Brown, Travis Zomer, Simon Parker, G. Gregory Haff

Research outputs 2022 to 2026

The purpose of this study was to investigate the validity of three wrist-worn devices for estimating energy expenditure (EE) and heart rate (HR) during close “Close Quarter Battle” (CQB). Fifty male soldiers (mean ± SD: age 30.9 ± 4.6 years, height: 1.81 ± 0.64 m and body mass 87.3 ± 7.7 kg) wore three activity monitors (Apple Watch 5, Garmin Forerunner® 935 and GENEActiv accelerometer), a Metamax 3B metabolic cart and a Polar chest strap, whilst conducting a CQB training activity (duration: 26.6 ± 5.0 min). EE and HR data from each test device were compared against criterion measures using …

Increasing Social Inclusion And Engagement Of Exercise For Individuals With Spinal Cord Injuries: A Universal Resource Development For Wellness Facilities, Alexa Hall

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

Individuals with spinal cord injuries (SCIs) are 1.5 times more likely to disengage in exercise one-year post-injury despite 80% of these individuals agreeing that exercise is critical to their overall health and quality of life (Baehr. Et al., 2022). A needs assessment was conducted on why the lack of engagement in exercise exists for individuals with SCIs within fitness facilities to identify barriers preventing participation. A quality improvement program called the Spinal Cord Injury Wellness Toolkit was created based off these findings and implemented at the MUSC Wellness Center. 14 individuals with SCIs participated at wellness center; REDCap surveys were …

Physical Activity And Amyloid Beta In Middle-Aged And Older Adults: A Systematic Review And Meta-Analysis, María Rodriguez-Ayllon, Patricio Solis-Urra, Cristina Arroyo-Ávila, Miriam Álvarez-Ortega, Pablo Molina-García, Cristina Molina-Hidalgo, Manuel Gómez-Río, Belinda Brown, Kirk I. Erickson, Irene Esteban-Cornejo

Research outputs 2022 to 2026

Background: One of the pathological hallmarks distinguishing Alzheimer's disease from other dementias is the accumulation of amyloid beta (A ). Higher physical activity is associated with decreased dementia risk, and one potential path could be through A levels modulation. We aimed to explore the relationship between physical activity and A in middle-aged and older adults. Methods: A systematic search of PubMed, Web of Science, PsycINFO, Cochrane Central Register of Controlled Trials, and SPORTDiscus was performed from inception to April 28, 2022. Studies were eligible if they included physical activity and A data in adults aged 45 years or older. Multi-level …

Assessments Used By Athletic Trainers To Decide Return-To-Activity Readiness In Patients With An Ankle Sprain, Ryan S. Mccann, Cailee E. Welch Bacon, Ashley M. B. Suttmiller, Phillip A. Gribble, Julie M. Cavallario

Rehabilitation Sciences Faculty Publications

Context: Athletic trainers (ATs) often care for patients with ankle sprains. Expert consensus has been established for rehabilitation-oriented assessments (ROASTs) that should be included in ankle-sprain evaluations. However, the methods ATs use to determine return-to-activity readiness after an ankle sprain are unknown.

Objectives: To identify ATs' methods for determining patients' return-to-activity readiness after an ankle sprain and demographic characteristics of the ATs and their methods.

Setting: Online survey.

Design: Cross-sectional study.

Patients or Other Participants: We recruited 10 000 clinically practicing ATs. A total of 676 accessed the survey, 574 submitted responses (85% completion rate), and 541 respondents met the …

Exercise Professional Education, Qualifications, And Certifications: A Content Analysis Of Job Postings In The United States, Rachele Pojednic, Devin P. O’Neill, Molly G. Flanagan, Alexis Bartlett, Byron L. G. Carter, Mary A. Kennedy

Research outputs 2022 to 2026

Introduction: Growth in the field of clinical exercise science and the potential impacts on overall health and wellbeing have driven the need for qualified, clinically trained, exercise professionals. And yet, it is not well understood what specific credentials employers are seeking when hiring exercise professionals. Purpose: The purpose of the study was to examine the qualification requirements for professionals seeking employment in exercise science, exercise physiology, kinesiology or equivalent fields. Methods: Search platforms Indeed.com and USAJobs.gov were examined within a two week period in 2022. Search terms included “Exercise Physiology”, “Exercise Science”, “Exercise Professional”, “Exercise Prescription”, “Exercise Specialist”, and “Kinesiology”. …