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Physical Activity And Amyloid Beta In Middle-Aged And Older Adults: A Systematic Review And Meta-Analysis, María Rodriguez-Ayllon, Patricio Solis-Urra, Cristina Arroyo-Ávila, Miriam Álvarez-Ortega, Pablo Molina-García, Cristina Molina-Hidalgo, Manuel Gómez-Río, Belinda Brown, Kirk I. Erickson, Irene Esteban-Cornejo

Research outputs 2022 to 2026

Background: One of the pathological hallmarks distinguishing Alzheimer's disease from other dementias is the accumulation of amyloid beta (A ). Higher physical activity is associated with decreased dementia risk, and one potential path could be through A levels modulation. We aimed to explore the relationship between physical activity and A in middle-aged and older adults. Methods: A systematic search of PubMed, Web of Science, PsycINFO, Cochrane Central Register of Controlled Trials, and SPORTDiscus was performed from inception to April 28, 2022. Studies were eligible if they included physical activity and A data in adults aged 45 years or older. Multi-level …