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Programmatic Desensitization Of The Cough Reflex In Patients With Refractory Chronic Cough, Emma Bozarth Dailey

Graduate Student Theses, Dissertations, & Professional Papers

Aim: The purpose of this blinded, randomized, placebo-controlled pilot clinical trial was to determine the potential of treating refractory chronic cough (RCC) using a progressive desensitization model paired with behavioral cough suppression.

Methods: Twelve adults with chronic cough who had failed behavioral cough treatment enrolled in and completed the study. Participants were randomly assigned to a treatment (n=8) or placebo group (n=4). The study consisted of three phases. During Phase I, participants completed baseline testing, including cough sensitivity testing with capsaicin, the Leicester Cough Questionnaire (LCQ), urge-to-cough-testing, and 24-hour cough frequency testing. During Phase II, participants practiced behavioral cough suppression …