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Full-Text Articles in Medicine and Health Sciences
Auditory And Somatosensory Pre-Pulse Inhibition In Mice, Anna Louthan
Auditory And Somatosensory Pre-Pulse Inhibition In Mice, Anna Louthan
Dissertations, 2014-2019
Both hearing and somatosensation are sensory responses to vibrations, and here we show a way to investigate such mechanoreceptive psychophysics alone and in combination. Pre-pulse inhibition (PPI) is a well-known, unconditioned, and reflexive technique for measuring sensory thresholds with a wide variety of stimuli and laboratory animals. In this paper, we explore interactions between auditory and somatosensory PPI in normal mice. Fifteen C57/BL6J mice were tested three times each. Ages varied between one and six months. Testing followed published procedures from our lab and others, except the pre-pulses were auditory, somatosensory (vibration of the test chamber), or both. The auditory …
Hearing Studies In Old Mice: The Effect Of Pre-Pulse Inhibition On The Acoustic Startle Response, Ashley B. Hillyard, Nicolette S. Chuss
Hearing Studies In Old Mice: The Effect Of Pre-Pulse Inhibition On The Acoustic Startle Response, Ashley B. Hillyard, Nicolette S. Chuss
Senior Honors Projects, 2010-2019
The purpose of this study pertains to hearing in the species Peromyscus maniculatus (deer mice) — specifically their responses to a startling sound. Approximately seven mice were tested between four and five years of age, approaching the lifespan of this species. By means of an accelerometer, which measures a reflexive, motor response, the mice were presented with an acoustic startle-eliciting stimulus (SES) — that is a loud, startling, unexpected sound. During the study, the mice were also presented with a softer, less-intense stimulus — known as a pre-pulse — slightly before the more intense sound. This pre-pulse stimulus was in …