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Sleep Deprivation And Recovery: The Effects Of P300 Three And Six Hours Post Recovery, Kimberly A. Brauer Jul 2016

Sleep Deprivation And Recovery: The Effects Of P300 Three And Six Hours Post Recovery, Kimberly A. Brauer

MSU Graduate Theses

The P300 waveform is an auditory evoked potential (AEP) elicited through a decision making process. Due to the endogenous nature of the P300 response, which requires participants to actively respond to an auditory stimuli, it has been used as on objective measure to evaluate the cognitive processes of attention and memory. Previous studies have looked at the P300 before and after sleep deprivation as well as after brief rest periods. Evidence shows that a decline in P300 amplitudes and increase in latency are seen after 24 hours of sleep deprivation and improvements in the P300 are seen after a recovery …


Spatial Irregularities Of Compound Action Potential Origination In Individual Cochleae, Kaitlyn M. Kennedy May 2016

Spatial Irregularities Of Compound Action Potential Origination In Individual Cochleae, Kaitlyn M. Kennedy

MSU Graduate Theses

The present study aims to evaluate the origin of compound action potential (CAP) responses in the guinea pig ear using the following method. Pipettes were sealed into the cochlear apex of 26 guinea pigs to inject ototoxic pharmaceuticals that inhibit nerve responses without affecting cochlear function. The rate of the injection was adjusted once each minute to account for variations in the diameter of the cochlea and to maintain a steady flow of pharmaceuticals. CAP measurements collected at around 90-second intervals using tone burst stimuli during the injections allowed evaluation of the neural responses over time. Responses to higher stimulation …