Medicine and Health Sciences Commons^™

Function-­Preserving Filters For Sampling In Biological Networks, Kathryn Dempsey Cooper, Sanjukta Bhowmick, Hesham Ali

Interdisciplinary Informatics Faculty Publications

Assays created to study systems of disease and aging can offer a whole new set of therapeutic targets. However, with experiments of this immense volume, data becomes unmanageable for many traditional analyses. Enter the biological network, a tool for modeling relationships among high-throughput data that is quickly rising in popularity. Small networks (in the order of hundreds to few thousands of nodes) use relationships between network structure to infer biological function; this relationship has been confirmed and used in many studies to advance the study of model organisms. Networks built for assessing entire genomes, or entire protein repertoires, however, tend …