Medicine and Health Sciences Commons^™

Gpr75 Deficiency Attenuates High Fat Diet-Driven Obesity And Glucose Intolerance, Sakib Hossain

NYMC Student Theses and Dissertations

Recently, a collaboration between Regeneron Pharmaceuticals and the Schwartzman-Garcia labs at New York Medical College published an exome sequencing study of individuals across the United Kingdom, United States, and Mexico which concluded that individuals possessing non-functioning, truncated mutations to the orphan g protein coupled receptor (GPCR), GPR75, had lower BMI and 54% reduced likelihood of obesity. The present study was undertaken to fully characterize the metabolic phenotype of Gpr75 deficient mice when fed a high fat diet (HFD) and explore potential mechanisms by which GPR75 activation links to increased adiposity and decreased glucose tolerance. After 14 weeks of HFD-feeding we …

Exercise − A Unique Endogenous Regulator Of Irisin, Bdnf, Leptin And Cortisol Against Depression, Gilmara Gomes De Assis, Pawel Cieszczyk

Baltic Journal of Health and Physical Activity

Depression is the most prevalent stress-related disorder affecting the population world-wide with potential for an eminent increase after the 2020 pandemic. The mechanisms through which metabolism is involved in depression and stress disorders have been extensively investigated. However, their assessment using exogenous measures is a current limitation. Exercise, as is well reported in animal studies, exerts a critical regulatory influence on the main factors known to participate in these mechanisms. This overview describes the role of cortisol, leptin, irisin and BDNF in the exercise physiology and the known mechanism through which these factors act in anti-depressant mechanisms. Furthermore, the exercise …

Evaluation Of Hippocampal Allostatic Load-Associated Factors In Animal Models Of Post-Traumatic Stress Disorder: Relevance To Human Ptsd, Dennis Parker Kelley

LSU Doctoral Dissertations

Post-traumatic stress disorder (PTSD) is associated with elevated allostatic load, nearly double the risk for metabolic syndrome, reduced hippocampal volume, and contextual memory processing deficits. Emerging evidence suggests that these stress effects may predispose individuals to the development of PTSD, and there is a known relationship between chronic stress and metabolic dysfunction. In this work, we utilized two rat models of PTSD to explore these connections. We used an acute predator odor stressor to investigate the relationship between PTSD-like behaviors and mitochondrial dysfunction in the hippocampus of rats, and we observed that conditioned place avoidance was associated with reduced mitochondrial …

Varied Levels Of Fructose Consumption Induce Physiological, Cognitive, And Mitochondrial Alterations In Aged Female Rats, Emilie L. Bjerring

Theses and Dissertations

Since the 1970s, fructose consumption has dramatically increased within the United States, as well as the world. While adolescents tend to be the largest consumer of fructose, mostly seen in the form of sugary beverages, the consequences of a high fructose diet started in adulthood can also have severe implications on physiological parameters as well as cognition. Several studies have linked fructose consumption to metabolic syndrome, a clustering of symptoms related to overall health, with particular emphasis placed on obesity, type II diabetes, and the relationship with Alzheimer’s Disease. These findings largely stem from the outcomes of studies on cognition, …

Therapeutic Potential Of A Ketogenic Diet In The Treatment Of Major Depressive Disorder, Jordan A. Murrin

Masters Theses, 2020-current

Major depressive disorder (MDD) is the second most common mental health condition and a leading cause of disability in the world. It is theorized that MDD develops from a combination of biological, psychological, and social stressors. The condition is typically treated using pharmaceuticals and psychotherapy. However, not all individuals with MDD have access to or choose to use these treatments, or may prefer to incorporate therapeutic lifestyle changes such as exercise, sleep, and healthy eating. Even with treatment, MDD can alter brain structure and function, leading to the development of comorbid mental health and chronic metabolic conditions like obesity, cardiovascular …

Blood Pressure Is Associated With Markers Of Endogenous Fat Metabolism, K Charlton, E Warensjo, Linda Tapsell, M Batterham, J O'Shea

Karen E. Charlton

No abstract provided.

Slides: Appropriate Sustainable Energy Technologies: A Light To The World, Lakshman D. Guruswamy, Jason B. Aamodt, Blake Feamster

2012 Energy Justice Conference and Technology Exposition (September 17-18)

Presenter: Jason Aamodt, Attorney; Adjunct Professor, University of Tulsa

15 slides

Saturated- And N-6 Polyunsaturated-Fat Diets Each Induce Ceramide Accumulation In Mouse Skeletal Muscle: Reversal And Improvement Of Glucose Tolerance By Lipid Metabolism Inhibitors, G Frangioudakis, J Garrard, K Raddatz, J L. Nadler, Todd W. Mitchell, Carsten Schmitz-Peiffer

Faculty of Health and Behavioural Sciences - Papers (Archive)

Lipid-induced insulin resistance is associated with intracellular accumulation of inhibitory intermediates depending on the prevalent fatty acid (FA) species. In cultured myotubes, ceramide and phosphatidic acid (PA) mediate the effects of the saturated FA palmitate and the unsaturated FA linoleate, respectively. We hypothesized that myriocin (MYR), an inhibitor of de novo ceramide synthesis, would protect against glucose intolerance in saturated fat-fed mice, while lisofylline (LSF), a functional inhibitor of PA synthesis, would protect unsaturated fat-fed mice. Mice were fed diets enriched in saturated fat, n-6 polyunsaturated fat, or chow for 6 wk. Saline, LSF (25 mg/kg · d), or MYR …

Plasticity Of Oxidative Metabolism In Variable Climates: Molecular Mechanisms, Frank Seebacher, Martin D. Brand, Paul Else, Helga Guderley, Anthony J. Hulbert, Christopher D. Moyes

Faculty of Health and Behavioural Sciences - Papers (Archive)

Converting food to chemical energy (ATP) that is usable by cells is a principal requirement to sustain life. The rate of ATP production has to be sufficient for housekeeping functions, such as protein synthesis and maintaining membrane potentials, as well as for growth and locomotion. Energy metabolism is temperature sensitive, and animals respond to environmental variability at different temporal levels, from within‐individual to evolutionary timescales. Here we review principal molecular mechanisms that underlie control of oxidative ATP production in response to climate variability. Nuclear transcription factors and coactivators control expression of mitochondrial proteins and abundance of mitochondria. Fatty acid and …

Conjugated Linoleic Acid Versus High-Oleic Acid Sunflower Oil: Effects On Energy Metabolism, Glucose Tolerance, Blood Lipids, Appetite And Body Composition In Regularly Exercising Individuals, Estelle V. Lambert, Julia H. Goedecke, Kerrie Bluett, Kerry Heggie, Amanda Claassen, Dale E. Rae, Sacha West, Jonathan Dugas, Lara Dugas, Shelly Meltzer, Karen E. Charlton, Inge Mohede

Faculty of Science, Medicine and Health - Papers: part A

The aim of this study was to measure the effects of 12 weeks of conjugated linoleic acid (CLA) supplementation on body composition, RER, RMR, blood lipid profiles, insulin sensitivity and appetite in exercising, normal-weight persons. In this double-blind, randomised, controlled trial, sixty-two non-obese subjects (twenty-five men, thirty-seven women) received either 3.9 g/d CLA or 3.9 g high-oleic acid sunflower oil for 12 weeks. Prior to and after 12 weeks of supplementation, oral glucose tolerance, blood lipid concentrations, body composition (dual-energy X-ray absorptiometry and computerised tomography scans), RMR, resting and exercising RER and appetite were measured. There were no significant effects …

Dietary Fats And Membrane Function: Implications For Metabolism And Disease, Anthony J. Hulbert, Nigel Turner, Leonard H. Storlein, Paul Else

Faculty of Health and Behavioural Sciences - Papers (Archive)

Lipids play varied and critical roles in metabolism, with function dramatically modulated by the individual fatty acid moities in complex lipid entities. In particular, the fatty acid composition of membrane lipids greatly influences membrane function. Here we consider the role of dietary fatty acid profile on membrane composition and, in turn, its impact on prevalent disease clusters of the metabolic syndrome and mental illness. Applying the classical physiological conformer-regulator paradigm to quantify the influence of dietary fats on membrane lipid composition (i.e. where the membrane variable is plotted against the same variable in the environment - in this case dietary …

Dietary N-3 And N-6 Fatty Acids Alter Avian Metabolism: Molecular-Species Compostiton Of Breast-Muscle Phospholipids, Ronald Newman, Wayne Bryden, Eva Fleck, John R. Ashes, Leonard Storlien, Jeffery A. Downing

Faculty of Science, Medicine and Health - Papers: part A

The effects of diets high in n-3 polyunsaturated fatty acids (PUFA; provided by fish oil), n-6 PUFA (sunflower oil) or in more-saturated fatty acids (tallow) on the distribution of subclasses of choline phospholipids (PC) and ethanolamine phospholipids (PE) from the breast muscle of broiler chickens were examined. Supplementation with the different fatty acids had no effect on the distribution of phospholipid subclasses. Feeding sunflower oil or tallow gave a molecular-species profile similar in both fatty acid subtype and proportion. In the diacyl PC phospholipids, 16: 0–18: 1n-9 and 16: 0–18: 2n-6 accounted for approximately …

Dietary N-3 And N-6 Fatty Acids Alter Avian Metabolism: Metabolism And Abdominal Fat Deposition, Ronald Newman, Wayne Bryden, Eva Fleck, John R. Ashes, William A. Buttemer, Leonard Storlien, Jeffery Downing

Faculty of Science, Medicine and Health - Papers: part A

The effects of dietary saturated fatty acids and polyunsaturated fatty acids (PUFA) of the n-3 and n-6 series on weight gain, body composition and substrate oxidation were investigated in broiler chickens. At 3 weeks of age three groups of chickens (n 30; ten birds per group) were fed the fat-enriched experimental diets for 5 weeks. These diets were isonitrogenous, isoenergetic and contained 208 g protein/kg and 80 g edible tallow, fish oil or sunflower oil/kg; the dietary fatty acid profiles were thus dominated by saturated fatty acids, n-3 PUFA or n-6 PUFA respectively. Resting RQ …