Medicine and Health Sciences Commons^™

Dna Methylation Signatures Of Chronic Low-Grade Inflammation Are Associated With Complex Diseases, Symen Ligthart, Carola Marzi, Stella Aslibekyan, Michael M. Mendelson, Karen N. Conneely, Toshiko Tanaka, Elena Colicino, Lindsay L. Waite, Roby Joehanes, Weihua Guan, Jennifer A. Brody, Cathy Elks, Riccardo Marioni, Min A. Jhun, Golareh Agha, Jan Bressler, Cavin K. Ward-Caviness, Brian H. Chen, Tianxiao Huan, Kelly Bakulski, Elias L. Salfati, Whi-Empc Investigators, Giovanni Fiorito, Charge Epigenetics Of Coronary Heart Disease, Simone Wahl, Katharina Schramm, Jin Sha, Dena G. Hernandez, Allan C. Just, Jennifer A. Smith, Donna K. Arnett

Epidemiology and Environmental Health Faculty Publications

Background: Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade inflammation may reveal novel pathways or therapeutic targets for inflammation.

Results: We performed a meta-analysis of epigenome-wide association studies (EWAS) of serum C-reactive protein (CRP), which is a sensitive marker of low-grade inflammation, in a large European population (n = 8863) and trans-ethnic replication in African Americans (n = 4111). We found differential methylation at 218 CpG sites to be associated with CRP (P < 1.15 × 10^–7) in the discovery panel …

Bahar And Zarrin, Bahar, Zarrin, Tsos

TSOS Interview Gallery

Bahar and Zarrin are friends living in Oinofyta Refugee Camp. They are both from Afghanistan but fled very different circumstances. Bahar lived in Iran with her husband until he passed, and she was rejected by her family. As a single woman she faced a life with little rights. Despite major health complications she fled to Greece in a boat. She now lives in the camp, struggling with repeated hospitalizations.

Zarrin left a life of comfort and privilege in Afghanistan and misses home greatly. Her husband was a wealthy businessman and Zarrin taught school. Thinking back on what they lost causes …

Zarrin, Zarrin, Tsos

TSOS Interview Gallery

My name is Zarrin. I was an English teacher. In Afghanistan I had a big house and a garden. My husband was a rich man; he had lots of money. My children studied in a private school.All the time the Taliban was warning my husband, “Why does your wife go to school and teach children? If your wife goes to school, we’ll throw acid on her face and take your children.” They don’t like education —they don’t like women attending school.Zarrin left a life of comfort and privilege in Afghanistan and misses home greatly. Her husband was a wealthy businessman …

Health And Psychosocial Outcomes Of A Telephonic Couples Behavior Change Intervention In Patients With Poorly Controlled Type 2 Diabetes: A Randomized Clinical Trial, Paula M. Trief, Lawrence Fisher, Jonathan G. Sandberg, Donald A. Cibula, Jacqueline Dimmock, Danielle M. Hessler, Patricia Forken, Ruth S. Weinstock

Faculty Publications

To compare glycemic control and secondary outcomes of a 4-month telephonic couples behavioral intervention to individual intervention, and to education, for adults with type 2 diabetes.

Social Incentives In Pervasive Fitness Apps For Obese And Diabetic Patients, Yu Chen, Mirana Randriambelonoro, Antoine Geissbuhler, Pearl Pu

Faculty Publications, Information Systems & Technology

Social incentives such as cooperation and competition are found to motivate users in pervasive fitness applications. This work investigates how social incentives work for individuals with obesity and diabetes. We used a mobile fitness application called HealthyTogether as an experimental platform, which allows dyads to achieve fitness goals together and compete in an online community. We conducted a fourweek study with 16 obese and diabetic patients who used HealthyTogether to exercise with a buddy. Results show that participants exercised more with social incentives compared with their baseline. Collaborating with buddies to compete in a community was reported as motivating for …

Depression In Mexican Americans With Diagnosed And Undiagnosed Diabetes, Rene L. Olvera, Susan P. Fisher-Hoch, Douglas E. Williamson, Kristina Vatcheva, Joseph B. Mccormick

School of Mathematical and Statistical Sciences Faculty Publications and Presentations

Background: Depression and diabetes commonly co-occur; however, the strength of the physiological effects of diabetes as mediating factors towards depression is uncertain.

Method: We analyzed extensive clinical, epidemiological and laboratory data from n = 2081 Mexican Americans aged 35-64 years, recruited from the community as part of the Cameron County Hispanic Cohort (CCHC) divided into three groups: Diagnosed (self-reported) diabetes (DD, n = 335), Undiagnosed diabetes (UD, n = 227) and No diabetes (ND, n = 1519). UD participants denied being diagnosed with diabetes, but on testing met the 2010 American Diabetes Association and World Health Organization definitions of diabetes. …

Diabetes Interaction Study: Communicating Understanding And Social Support, Dana K. May

Wayne State University Dissertations

The current study evaluated a brief individualized feedback intervention developed to improve communication style of parents with an adolescent with type 1 diabetes. Seventy-nine parent-adolescent dyads (13-18 years) were randomized to receive a single session of brief feedback to target parental person-centered communication skills (n = 39) or to receive an educational comparison group (n = 40). Families were asked to discuss a diabetes related problem. A clinician concurrently rated the parent’s communication skills to identify communication strengths and weaknesses. Parents in the feedback group received feedback on their use of person-centered communication during the conversation using motivational interviewing techniques. …

Access And Barriers To Care During Transition From Active Duty To Veteran Status In Veterans With Diabetes: A Look At Health Literacy, Change, And Ongoing Diabetes Self-Management Education, Mark R. Malebranche

Dissertations

Background and Rationale: Transition from active duty to veteran status may be a challenging time, especially for veterans with diabetes. These veterans face multiple changes that can cause distress. Most veterans with diabetes have type 2 diabetes, however a diagnosis of type 1 diabetes on active duty is cause for discharge for active duty.

Purposes and Aims: The purpose of this study was to describe the transition experience of veterans diagnosed with diabetes while on active duty from active duty to veteran status. The study describes barriers and facilitators to healthcare and diabetes self-care management. The four aims of the …