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Comparability Of Functional Mri Response In Young And Old During Inhibition, Kristy Nielson, Scott Langenecker, T Ross, H Garavan, S Rao, E Stein
Comparability Of Functional Mri Response In Young And Old During Inhibition, Kristy Nielson, Scott Langenecker, T Ross, H Garavan, S Rao, E Stein
Kristy Nielson
When using fMRI to study age-related cognitive changes, it is important to establish the integrity of the hemodynamic response because, potentially, it can be affected by age and disease. However, there have been few attempts to document such integrity and no attempts using higher cognitive rather than perceptual or motor tasks. We used fMRI with 28 healthy young and older adults on an inhibitory control task. Although older and young adults differed in task performance and activation patterns, they had comparable hemodynamic responses. We conclude that activation during cognitive inhibition, which was predominantly increased in elders, was not due to …
Medial Temporal Lobe Activity For Recognition Of Recent And Remote Famous Names: An Event-Related Fmri Study, K Douville, J L. Woodard, M Seidenberg, S K. Miller, C L. Leveroni, Kristy Nielson, M Franczak, P Antuono, S M. Rao
Medial Temporal Lobe Activity For Recognition Of Recent And Remote Famous Names: An Event-Related Fmri Study, K Douville, J L. Woodard, M Seidenberg, S K. Miller, C L. Leveroni, Kristy Nielson, M Franczak, P Antuono, S M. Rao
Kristy Nielson
Previous neuroimaging studies examining recognition of famous faces have identified activation of an extensive bilateral neural network [Gorno Tempini, M. L., Price, C. J., Josephs, O., Vandenberghe, R., Cappa, S. F., Kapur, N. et al. (1998). The neural systems sustaining face and proper-name processing. Brain, 121, 2103–2118], including the medial temporal lobe (MTL) and specifically the hippocampal complex [Haist, F., Bowden, G. J., & Mao, H. (2001). Consolidation of human memory over decades revealed by functional magnetic resonance imaging. Nature Neuroscience, 4, 1139–1145; Leveroni, C. L., Seidenberg, M., Mayer, A. R., Mead, L. A., Binder, J. R., & Rao, S. …