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Full-Text Articles in Medicine and Health Sciences
Diet Quality In Patients With End-Stage Kidney Disease Undergoing Dialysis, Lauren Roach, Kelly Lambert, Jane Holt, Barbara J. Meyer
Diet Quality In Patients With End-Stage Kidney Disease Undergoing Dialysis, Lauren Roach, Kelly Lambert, Jane Holt, Barbara J. Meyer
Faculty of Science, Medicine and Health - Papers: part A
ACKGROUND: People on haemodialysis (HD) are at risk of consuming a poor quality diet. This includes inadequate intake of omega-3 long chain polyunsaturated fatty acids (n-3 LCPUFA). OBJECTIVE: This study aims to investigate diet quality, with a particular focus on n-3 LCPUFA intake, in a population of incentre HD patients. DESIGN: Dietary intake was measured using three 24 hour recalls; the Polyunsaturated food frequency questionnaire (PUFA FFQ) and the Total Diet Score (TDS). Dietary intake was also compared to evidence based practice guidelines (EBPG). Nutritional status was assessed using the Patient Generated Subjective Global Assessment (PG SGA). SUBJECTS: A total …
Identifying Metabolic Syndrome In A Clinical Cohort: Implications For Prevention Of Chronic Disease, Allison Martin, Elizabeth Neale, Marijka Batterham, Linda C. Tapsell
Identifying Metabolic Syndrome In A Clinical Cohort: Implications For Prevention Of Chronic Disease, Allison Martin, Elizabeth Neale, Marijka Batterham, Linda C. Tapsell
Faculty of Science, Medicine and Health - Papers: part A
In the clinical setting, calculating cardiovascular disease (CVD) risk is commonplace but the utility of the harmonised equation for metabolic syndrome (MetS) (Alberti et al., 2009) is less well established. The aims of this study were to apply this equation to an overweight clinical cohort to identify risk factors for being metabolically unhealthy and explore associations with chronic disease. Baseline data were analysed from a lifestyle intervention trial of Illawarra residents recruited in 2014/2015. Participants were aged 25–54 years with a BMI 25–40 kg/m2. Data included MetS, CVD risk, insulin sensitivity, weight, body fat, diet, peripheral artery disease (PAD), physical …
Daedalic Dna Vaccination Against Self Antigens As A Treatment For Chronic Kidney Disease, Yuan Min Wang, Jimmy Jianheng Zhou, Ya Wang, Debbie Watson, Geoff Yu Zhang, Min Hu, Huiling Wu, Guoping Zheng, Yiping Wang, Anne M. Durkan, David Ch Harris, Stephen I. Alexander
Daedalic Dna Vaccination Against Self Antigens As A Treatment For Chronic Kidney Disease, Yuan Min Wang, Jimmy Jianheng Zhou, Ya Wang, Debbie Watson, Geoff Yu Zhang, Min Hu, Huiling Wu, Guoping Zheng, Yiping Wang, Anne M. Durkan, David Ch Harris, Stephen I. Alexander
Faculty of Science, Medicine and Health - Papers: part A
Chronic kidney disease (CKD) is a major cause of death and morbidity in Australia and worldwide. DNA vaccination has been used for targeting foreign antigens to induce immune responses and prevent autoimmune disease, viral infection and cancer. However, the use of DNA vaccination has been restricted by a limited ability to induce strong immune responses, especially against self-antigens which are limited by mechanisms of self-tolerance. Furthermore, there have been few studies on the potential of DNA vaccination in chronic inflammatory diseases, including CKD. We have established strategies of DNA vaccination targeting specific self-antigens in the immune system including co-stimulatory pathways, …
Patients Communicating With Their Primary Care Physician About Chronic Disease Treatment In Regional Australia: Is Health Literacy Important?, J Mullan, K Weston, A Bonney, C Magee, G Albert, B Gerges, Soheir Abadier, T Smith, V Bonney, B Dijkmans-Hadley, C Kielly-Carroll
Patients Communicating With Their Primary Care Physician About Chronic Disease Treatment In Regional Australia: Is Health Literacy Important?, J Mullan, K Weston, A Bonney, C Magee, G Albert, B Gerges, Soheir Abadier, T Smith, V Bonney, B Dijkmans-Hadley, C Kielly-Carroll
Faculty of Science, Medicine and Health - Papers: part A
No abstract provided.
Deletion Of Abca7 Increases Cerebral Amyloid-Β Accumulation In The J20 Mouse Model Of Alzheimer's Disease, Woojin S. Kim, Hongyun Li, Kalani Ruberu, Sharon Chan, David A. Elliott, Jac Kee Low, David Cheng, Tim Karl, Brett Garner
Deletion Of Abca7 Increases Cerebral Amyloid-Β Accumulation In The J20 Mouse Model Of Alzheimer's Disease, Woojin S. Kim, Hongyun Li, Kalani Ruberu, Sharon Chan, David A. Elliott, Jac Kee Low, David Cheng, Tim Karl, Brett Garner
Faculty of Science, Medicine and Health - Papers: part A
ATP-binding cassette transporter A7 (ABCA7) is expressed in the brain and has been detected in macrophages, microglia, and neurons. ABCA7 promotes efflux of lipids from cells to apolipoproteins and can also regulate phagocytosis and modulate processing of amyloid precursor protein (APP) to generate the Alzheimer's disease (AD) amyloid-β (Aβ) peptide. Genome-wide association studies have indicated that ABCA7 single nucleotide polymorphisms confer increased risk for late-onset AD; however, the role that ABCA7 plays in the brain in the AD context is unknown. In the present study, we crossed ABCA7-deficient (A7-/-) mice with J20 amyloidogenic mice to address this issue. We show …
Dairy Consumption And The Risk Of 15-Year Cardiovascular Disease Mortality In A Cohort Of Older Australians, Jimmy Chun Yu Louie, Victoria M. Flood, George Burlutsky, Anna M. Rangan, Timothy P. Gill, Paul Mitchell
Dairy Consumption And The Risk Of 15-Year Cardiovascular Disease Mortality In A Cohort Of Older Australians, Jimmy Chun Yu Louie, Victoria M. Flood, George Burlutsky, Anna M. Rangan, Timothy P. Gill, Paul Mitchell
Faculty of Science, Medicine and Health - Papers: part A
The effects of habitual dairy consumption and the risk of 15-year cardiovascular disease (CVD) mortality in a cohort of older Australians were investigated. Participants (n = 2900) completed a validated 145-item semi-quantitative food frequency questionnaire. Cox proportional hazards regression models were used to investigate associations between tertiles of the dairy consumption, including low/reduced fat dairy, whole fat dairy and their ratio (ratioLF/WF), and risk of mortality from coronary heart disease (CHD), stroke or combined CVD. There were 548 recorded cases of CVD mortality in this cohort. For total dairy intake, a reduction in risk of CVD was only seen in …
A Proposed Approach To Monitor Private-Sector Policies And Practices Related To Food Environments, Obesity And Non-Communicable Disease Prevention, G Sacks, B Swinburn, V Kraak, S Downs, C Walker, S Barquera, S Friel, C Hawkes, B Kelly, S Kumanyika, M L'Abbe, A Lee, T Lobstein, J Ma, J Macmullan, S Mohan, C Monteiro, B Neal, M Rayner, D Sanders, W Snowdon, S Vandevijvere
A Proposed Approach To Monitor Private-Sector Policies And Practices Related To Food Environments, Obesity And Non-Communicable Disease Prevention, G Sacks, B Swinburn, V Kraak, S Downs, C Walker, S Barquera, S Friel, C Hawkes, B Kelly, S Kumanyika, M L'Abbe, A Lee, T Lobstein, J Ma, J Macmullan, S Mohan, C Monteiro, B Neal, M Rayner, D Sanders, W Snowdon, S Vandevijvere
Faculty of Science, Medicine and Health - Papers: part A
Private-sector organizations play a critical role in shaping the food environments of individuals and populations. However, there is currently very limited independent monitoring of private-sector actions related to food environments. This paper reviews previous efforts to monitor the private sector in this area, and outlines a proposed approach to monitor private-sector policies and practices related to food environments, and their influence on obesity and non-communicable disease (NCD) prevention. A step-wise approach to data collection is recommended, in which the first ('minimal') step is the collation of publicly available food and nutrition-related policies of selected private-sector organizations. The second ('expanded') step …
From Research To Policy In Chronic Disease Prevention: Mandatory Salt Reduction In South Africa, K Charlton, K Steyn, N Levitt, C Lombard
From Research To Policy In Chronic Disease Prevention: Mandatory Salt Reduction In South Africa, K Charlton, K Steyn, N Levitt, C Lombard
Faculty of Science, Medicine and Health - Papers: part A
Abstract of a poster that presented at 20th International Congress of Nutrition, Granada, Spain, September 15-20, 2013.
Preventive Evidence Into Practice (Pep) Study: Implementation Of Guidelines To Prevent Primary Vascular Disease In General Practice Protocol For A Cluster Randomised Controlled Trial, Mark Fort Harris, Jane Lloyd, John Litt, Mieke Van Driel, Danielle Mazza, Grant Russell, Jane Smith, Chris Del Mar, Elizabeth Denney-Wilson, Sharon M. Parker, Yordanka Krastev, Upali W. Jayasinghe, Richard J. Taylor, Nicholas Zwar, Jinty Wilson, Helen Bolger-Harris, Justine Waters
Preventive Evidence Into Practice (Pep) Study: Implementation Of Guidelines To Prevent Primary Vascular Disease In General Practice Protocol For A Cluster Randomised Controlled Trial, Mark Fort Harris, Jane Lloyd, John Litt, Mieke Van Driel, Danielle Mazza, Grant Russell, Jane Smith, Chris Del Mar, Elizabeth Denney-Wilson, Sharon M. Parker, Yordanka Krastev, Upali W. Jayasinghe, Richard J. Taylor, Nicholas Zwar, Jinty Wilson, Helen Bolger-Harris, Justine Waters
Faculty of Science, Medicine and Health - Papers: part A
Background: There are significant gaps in the implementation and uptake of evidence-based guideline recommendations for cardiovascular disease (CVD) and diabetes in Australian general practice. This study protocol describes the methodology for a cluster randomised trial to evaluate the effectiveness of a model that aims to improve the implementation of these guidelines in Australian general practice developed by a collaboration between researchers, non-government organisations, and the profession.Methods: We hypothesise that the intervention will alter the behaviour of clinicians and patients resulting in improvements of recording of lifestyle and physiological risk factors (by 20%) and increased adherence to guideline recommendations for: the …
Understanding And Benchmarking Health Service Achievement Of Policy Goals For Chronic Disease, Erica Bell, Bastian Seidel
Understanding And Benchmarking Health Service Achievement Of Policy Goals For Chronic Disease, Erica Bell, Bastian Seidel
Faculty of Science, Medicine and Health - Papers: part A
Background Key challenges in benchmarking health service achievement of policy goals in areas such as chronic disease are: 1) developing indicators and understanding how policy goals might work as indicators of service performance; 2) developing methods for economically collecting and reporting stakeholder perceptions; 3) combining and sharing data about the performance of organizations; 4) interpreting outcome measures; 5) obtaining actionable benchmarking information. This study aimed to explore how a new Boolean-based small-N method from the social sciences—Qualitative Comparative Analysis or QCA—could contribute to meeting these internationally shared challenges. Methods A ‘multi-value QCA’ (MVQCA) analysis was conducted of data from 24 …
Short And Long Sleep Duration Are Associated With Prevalent Cardiovascular Disease In Australian Adults, Christopher A. Magee, Len Kritharides, John Attia, Patrick Mcelduff, Emily Banks
Short And Long Sleep Duration Are Associated With Prevalent Cardiovascular Disease In Australian Adults, Christopher A. Magee, Len Kritharides, John Attia, Patrick Mcelduff, Emily Banks
Faculty of Health and Behavioural Sciences - Papers (Archive)
A growing number of studies from a range of different countries have observed an association between sleep duration and cardiovascular disease. The objective of this paper was to examine the associations between sleep duration and prevalent cardiovascular disease in a large sample of Australian adults, and identify the sociodemographic and health-related factors moderating these associations. Participants included 218 155 Australian adults aged 45 years and over. The results indicated that 6 h versus 7 h sleep was associated with increased odds of heart disease [odds ratio (OR) = 1.11 (1.06–1.17)], diabetes [OR = 1.15 (1.09–1.22)], stroke [OR = 1.25 (1.14–1.38)] …
Is Seladin-1 Really A Selective Alzheimer's Disease Indicator?, Laura J. Sharpe, Jenny Wong, Brett Garner, Glenda M. Halliday, Andrew J. Brown
Is Seladin-1 Really A Selective Alzheimer's Disease Indicator?, Laura J. Sharpe, Jenny Wong, Brett Garner, Glenda M. Halliday, Andrew J. Brown
Faculty of Science, Medicine and Health - Papers: part A
Selective Alzheimer's Disease Indicator-1 (Seladin-1) was originally identified by its down-regulation in the brains of Alzheimer's disease (AD) patients. Here, we re-examine existing data and present new gene expression data that refutes its role as a selective AD indicator. Furthermore, we caution against the use of the name “Seladin-1” and instead recommend adoption of the approved nomenclature, 3β-hydroxysterol Δ24-reductase (or DHCR24), which describes its catalytic function in cholesterol synthesis. Further work is required to determine what link, if any, exists between DHCR24 and AD.
Disease Awareness Advertising: Women's Intentions Following Exposure, Danika Hall, Sandra C. Jones, Donald C. Iverson
Disease Awareness Advertising: Women's Intentions Following Exposure, Danika Hall, Sandra C. Jones, Donald C. Iverson
Faculty of Health and Behavioural Sciences - Papers (Archive)
Background: In Australia, where direct to consumer advertising of prescription medicines is prohibited, pharmaceutical companies can sponsor disease awareness advertising targeting consumers. This study examined the impact of disease awareness advertising exposure on older women's reported behavioural intentions. Method: Women were approached in a shopping centre and randomly assigned mock advertisements for two health conditions. Disease information and sponsors were manipulated. Results: Two hundred and forty-one women responded to 466 advertisements. Almost half reported an intention to ask their doctor for a prescription or referral as a result of seeing the advertisement, but more reported they would talk to their …
Effects Of Dairy Products On Crohn's Disease Symptoms Are Influenced By Fat Content And Disease Location But Not Lactose Content Or Disease Activity Status In A New Zealand Population, Deborah Nolan, Linda C. Tapsell, Rong Hu, Dug Yeo Han, Lynnette Ferguson
Effects Of Dairy Products On Crohn's Disease Symptoms Are Influenced By Fat Content And Disease Location But Not Lactose Content Or Disease Activity Status In A New Zealand Population, Deborah Nolan, Linda C. Tapsell, Rong Hu, Dug Yeo Han, Lynnette Ferguson
Faculty of Health and Behavioural Sciences - Papers (Archive)
Background Dairy products have been perceived as having the potential to cause adverse effects in individuals with Crohn’s disease (CD) and are often avoided, potentially increasing the risk of osteoporosis and related morbidity associated with inadequate dietary calcium intake. Objective To evaluate the self-reported effects of dairy products on CD symptoms and to determine whether these effects differed between types of dairy products consumed and disease state or location. Design Secondary analysis of dietary survey and clinical data from participants in the Genes and Diet in Inflammatory Bowel Disease study based in Auckland, New Zealand. Subjects/setting One hundred and sixty-five …
Genetic Adult Lactase Persistence Is Associated With Risk Of Crohn's Disease In A New Zealand Population, Deborah Nolan, Dug Yeo Han, Wen Jiun Lam, Angharad R. Morgan, Alan G. Fraser, Linda C. Tapsell, Lynnette R. Ferguson
Genetic Adult Lactase Persistence Is Associated With Risk Of Crohn's Disease In A New Zealand Population, Deborah Nolan, Dug Yeo Han, Wen Jiun Lam, Angharad R. Morgan, Alan G. Fraser, Linda C. Tapsell, Lynnette R. Ferguson
Faculty of Health and Behavioural Sciences - Papers (Archive)
Background Mycobacterium avium subspecies paratuberculosis (MAP) is an infective agent found in ruminants and milk products, which has been suggested to increase the risk of gastrointestinal inflammation in genetically susceptible hosts. It is hypothesized that lactase persistence facilitates exposure to such milk products increasing the likelihood of adverse outcomes. Individuals either homozygous or heterozygous for the T allele of DNA variant, rs4988235, located 14kb upstream from the LCT locus, are associated with having lactase persistence. The aim of this study was to determine whether lactase persistence as evident by the T allele of rs4988235 is associated with Crohn’s Disease (CD) …
Short Term Effects Of Energy Restriction And Dietary Fat Sub-Type On Weight Loss And Disease Risk Factors, Linda C. Tapsell, Marijka Batterham, Xu-Feng Huang, Sze Yen Tan, Grigorijs Teuss, Karen E. Charlton, Jane E. O'Shea, Eva M. Warensjo
Short Term Effects Of Energy Restriction And Dietary Fat Sub-Type On Weight Loss And Disease Risk Factors, Linda C. Tapsell, Marijka Batterham, Xu-Feng Huang, Sze Yen Tan, Grigorijs Teuss, Karen E. Charlton, Jane E. O'Shea, Eva M. Warensjo
Faculty of Health and Behavioural Sciences - Papers (Archive)
Background and aims: Decreasing energy intake relative to energy expenditure is the indisputable tenet of weight loss. In addition to caloric restriction modification of the type of dietary fat may provide further benefits. The aim of the present study was to examine the effect of energy restriction alone and with dietary fat modification on weight loss and adiposity, as well as on risk factors for obesity related disease. Methods and results: One-hundred and fifty overweight men and women were randomized into a 3 month controlled trial with four low fat (30% energy) dietary arms: (1) isocaloric (LF); (2) isocaloric with …
Lipids And Alzheimer's Disease, Brett Garner
Lipids And Alzheimer's Disease, Brett Garner
Faculty of Science, Medicine and Health - Papers: part A
According to the World Health Organisation (WHO), the number of people suffering from Alzheimer's disease (AD) worldwide is around 18 million. The prevalence of AD doubles every five years between 65 and 85 years of age and it is estimated that due to the ageing population, 34 million people will suffer from AD by 2025. The WHO has also stated that if AD onset were delayed by 5 years, the number of cases worldwide could be halved. Currently there are no curative or disease-stalling treatments for AD and a major research effort is underway in order to better understand the …
Uptake Of Medicare Chronic Disease Items In Australia By General Practice Nurses And Aboriginal Health Workers, Elizabeth J. Halcomb, Patricia M. Davidson, Nicola Brown
Uptake Of Medicare Chronic Disease Items In Australia By General Practice Nurses And Aboriginal Health Workers, Elizabeth J. Halcomb, Patricia M. Davidson, Nicola Brown
Faculty of Science, Medicine and Health - Papers: part A
The Australian health care system is currently in a state of reform and there is increasing pressure to provide care in community settings. Rising costs, demands and population ageing underscore the importance of adopting models of health care delivery to address changing epidemiological patterns. Population ageing and the increase of chronic conditions challenge models based on acute care. Changes to the Medicare benefits schedule have facilitated the development of a range of expanded nursing services in the general practice setting. In particular, item number 10997 was introduced to reimburse practice nurses and Aboriginal health workers (AHWs) for providing monitoring and …
Disease Awareness Advertisements In Australian Magazines: An Analysis Of Content And Compliance, Danika Hall, Sandra C. Jones, Donald C. Iverson
Disease Awareness Advertisements In Australian Magazines: An Analysis Of Content And Compliance, Danika Hall, Sandra C. Jones, Donald C. Iverson
Faculty of Health and Behavioural Sciences - Papers (Archive)
In Australia, Direct to Consumer Advertising (DTCA) of prescription medicine is prohibited; however pharmaceutical companies can communicate directly with consumers via Disease Awareness Advertising (DAA). DAA can contain information about a disease including treatment information, but cannot mention the name of a particular product or brand. DAA is currently regulated by the industry body Medicines Australia (MA). In the current study, content analysis methodology was used to determine the extent and nature of DAA in popular Australian women’s magazines which were monitored for 12 months. Findings relating to the use of visual appeals in the imagery and rational appeals in …
Industry Partnerships For Health Nonprofits And Disease Awareness Advertising, Danika Hall, Sandra C. Jones, Donald C. Iverson
Industry Partnerships For Health Nonprofits And Disease Awareness Advertising, Danika Hall, Sandra C. Jones, Donald C. Iverson
Faculty of Health and Behavioural Sciences - Papers (Archive)
Marketing partnerships between non-profit organisations (NPOs) and industry generally bring favourable results for both parties (Brønn and Vrioni 2001; Varadarajan and Menon 1988). However, there is some scepticism about corporate exploitation of such arrangements and growing concern in Australia and elsewhere about partnerships between the pharmaceutical industry and NPOs (Angell 2006; Moynihan and Cassels 2005) and the co-sponsorship of Disease Awareness Advertising (DAA). This paper reports the findings from a study of how Australian women respond to DAA with differing sponsors including their ability to identify, and their attitude toward, the sponsor. The results are of importance for health NPOs …
Content Analysis Of Disease Awareness Advertisements In Popular Australian Women's Magazines, Danika V. Hall, Sandra C. Jones, Donald C. Iverson
Content Analysis Of Disease Awareness Advertisements In Popular Australian Women's Magazines, Danika V. Hall, Sandra C. Jones, Donald C. Iverson
Faculty of Health and Behavioural Sciences - Papers (Archive)
Objective: To examine the nature of disease awareness advertising (DAA). Design: Therapeutic advertisements in six popular Australian women’s magazines were monitored between April 2006 and March 2007. A subset of advertisements was included in the study based on criteria derived from a definition of DAA. Unique advertisements were analysed by four independent coders. Main outcome measures: Types of advertisements and their sponsors, the types of disease information present, and the persuasive techniques utilised. Results: Of 711 advertisements identified, 60 met the inclusion criteria for DAA, and 30 of these were unique. Over one-third of the advertisements were classified as “unbranded …
Unrealistic Pessimism About Risk Of Coronary Heart Disease And Stroke In Patients With Type 2 Diabetes, Koula G. Asimakopoulou, Timothy Chas Skinner, Jennifer Spimpolo, Sally Marsh, Charles Fox
Unrealistic Pessimism About Risk Of Coronary Heart Disease And Stroke In Patients With Type 2 Diabetes, Koula G. Asimakopoulou, Timothy Chas Skinner, Jennifer Spimpolo, Sally Marsh, Charles Fox
Faculty of Health and Behavioural Sciences - Papers (Archive)
OBJECTIVE: We examined the accuracy of type 2 diabetes (T2D) patients risk estimates of developing Coronary Heart Disease (CHD)/ having a stroke as a consequence of diabetes and their mood about these risks. METHODS: Patients reported their perceived risks of developing CHD/ having a stroke and rated their mood about these risks using a self-report measure. Using an objective risk calculator, they were then told their actual risk of CHD and stroke and their mood was re-assessed. RESULTS: Patients estimates of their risk of CHD / stroke were grossly inflated. A negative relationship between disease risk and mood was also …
The Chronic Heart-Failure Assistance By Telephone (Chat) Study: Assessment Of Telephone Support For Vulnerable Patients With Chronic Disease, Julie Yallop, Bianca Chan, Leon Piterman, Andrew Tonkin, Andrew Forbes, Patricia M. Davidson, Robyn Clark, Elizabeth Halcomb, Andrea Nangle, Simon Stewart, Joanne Croucher, Henry Krum
The Chronic Heart-Failure Assistance By Telephone (Chat) Study: Assessment Of Telephone Support For Vulnerable Patients With Chronic Disease, Julie Yallop, Bianca Chan, Leon Piterman, Andrew Tonkin, Andrew Forbes, Patricia M. Davidson, Robyn Clark, Elizabeth Halcomb, Andrea Nangle, Simon Stewart, Joanne Croucher, Henry Krum
Faculty of Science, Medicine and Health - Papers: part A
Aim: To determine whether telephone support using an evidence-based protocol for chronic heart failure (CHF) management will improve patient outcomes and will reduce hospital readmission rates in patients without access to hospital-based management programs. Methods: The rationale and protocol for a cluster-design randomised controlled trial (RCT) of a semi-automated telephone intervention for the management of CHF, the Chronic Heart-failure Assistance by Telephone (CHAT) Study is described. Care is coordinated by trained cardiac nurses located in Heartline, the national call center of the National Heart Foundation of Australia in partnership with patients' general practitioners (GPs). Conclusions: The CHAT Study model represents …
Importance Of Soy Protein And Isoflavone Intake For Protection Against Heart Disease, A Thorp, J Buckley, A Coates, Trevor A Mori, Jo Hodgson, Jackie Mansour, Peter Howe, Barbara Meyer
Importance Of Soy Protein And Isoflavone Intake For Protection Against Heart Disease, A Thorp, J Buckley, A Coates, Trevor A Mori, Jo Hodgson, Jackie Mansour, Peter Howe, Barbara Meyer
Faculty of Health and Behavioural Sciences - Papers (Archive)
Abstract presented at The 2006 Annual Scientific Meeting of the Nutrition Society of Australia, 29 November - 2 December, Sydney, Australia
Dietary Fats And Membrane Function: Implications For Metabolism And Disease, Anthony J. Hulbert, Nigel Turner, Leonard H. Storlein, Paul Else
Dietary Fats And Membrane Function: Implications For Metabolism And Disease, Anthony J. Hulbert, Nigel Turner, Leonard H. Storlein, Paul Else
Faculty of Health and Behavioural Sciences - Papers (Archive)
Lipids play varied and critical roles in metabolism, with function dramatically modulated by the individual fatty acid moities in complex lipid entities. In particular, the fatty acid composition of membrane lipids greatly influences membrane function. Here we consider the role of dietary fatty acid profile on membrane composition and, in turn, its impact on prevalent disease clusters of the metabolic syndrome and mental illness. Applying the classical physiological conformer-regulator paradigm to quantify the influence of dietary fats on membrane lipid composition (i.e. where the membrane variable is plotted against the same variable in the environment - in this case dietary …
Systemic Levels Of Interleukin-6 And Matrix Metalloproteinase-9 In Patients With Multiple Myeloma May Be Useful As Prognostic Indexes Of Bone Disease, Aikaterini Sfiridaki, Spyridon Miyakis, George Tsirakis, Athanasios Alegakis, Andreas M. Passam, Ermioni Kandidaki, Andrerw N. Margioris, Michael Alexandrakis
Systemic Levels Of Interleukin-6 And Matrix Metalloproteinase-9 In Patients With Multiple Myeloma May Be Useful As Prognostic Indexes Of Bone Disease, Aikaterini Sfiridaki, Spyridon Miyakis, George Tsirakis, Athanasios Alegakis, Andreas M. Passam, Ermioni Kandidaki, Andrerw N. Margioris, Michael Alexandrakis
Faculty of Science, Medicine and Health - Papers: part A
Multiple myeloma is characterized by accelerated production of the proteolytic enzyme matrix metalloproteinase (MMP)-9. We hypothesized that myeloma- produced MMP-9 may influence the rate of bone turnover in a paracrine manner. Thus, we examined the correlations of MMP-9 levels, disease severity, and bone turnover rate as evaluated by markers of bone formation and resorption. Thirty-seven newly diagnosed multiple myeloma patients (nine of Durie-Salmon stage I, 12 of stage II and 16 of stage III) and 12 age-matched controls were studied. Serum MMP-9 levels were significantly higher at stage II compared to stage I (188.78"91.27 vs. 59.25"33.09 ng/mL, p-0.004). Additionally, free …
Beta-2 Glycoprotein1: Function In Health And Disease, Spyridon Miyakis, Bill Giannakopoulos, S A. Krilis
Beta-2 Glycoprotein1: Function In Health And Disease, Spyridon Miyakis, Bill Giannakopoulos, S A. Krilis
Faculty of Science, Medicine and Health - Papers: part A
Beta-2 glycoprotein I (β2GPI) is the principal target of autoantibodies in the antiphospholipid syndrome (APS). It is abundant in human plasma and shares high homology between different mammalian species. Although the exact physiological function of β2GPI has not been fully elucidated, several interactions have been described with other proteins and with negatively charged surfaces, such as anionic phospholipids, dextran and heparin. β2GPI is involved in the coagulation pathway, exerting both procoagulant and anticoagulant activities. Plasma from β2GPI-deficient mice exhibits impaired thrombin generation in vitro. Recently, it has been demonstrated that β2GPI binds factor (F) XI in vitro at concentrations lower …
Food And Nutritional Supplements. Their Role In Health And Disease, Anne-Therese Mcmahon
Food And Nutritional Supplements. Their Role In Health And Disease, Anne-Therese Mcmahon
Faculty of Science, Medicine and Health - Papers: part A
Book review of: Food and nutritional supplements. Their role in health and disease J K Ransley, J K Donnelly and NW Read (eds) Springer-Verlag Berlin, 2001. ISBN 3-540-41737-0 197pp c. A$120