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Comt And Oprm1 Genotype Associations With Daily Knee Pain Variability And Activity Induced Pain, Lynn M. Martire, Stephanie J. Wilson, Brent J. Small, Yvette P. Conley, Piotr K. Janicki, Martin J. Sliwinski
Comt And Oprm1 Genotype Associations With Daily Knee Pain Variability And Activity Induced Pain, Lynn M. Martire, Stephanie J. Wilson, Brent J. Small, Yvette P. Conley, Piotr K. Janicki, Martin J. Sliwinski
Aging Studies Faculty Publications
Background: Osteoarthritis (OA) of the knee is a common and increasingly prevalent condition that is one of the primary causes of chronic pain. Staying physically active protects against disability from knee OA but is also very challenging. A critical but unexamined question is whether patients at greatest risk for becoming less active are those with a genetic predisposition for greater sensitivity to daily pain.
Aims: We examined day-to-day variability in knee OA pain for patients with different variants of catechol-O-methyltransferase (COMT) and mu-opioid receptor (OPRM1) single nucleotide polymorphisms (SNPs), and whether patients with a specific genotype experience more pain following …