Medicine and Health Sciences Commons^™

Gene X Environment Effects Of Serotonin Transporter, Dopamine Receptor D4, And Monoamine Oxidase A Genes With Contextual And Parenting Risk Factors On Symptoms Of Oppositional Defiant Disorder, Anxiety, And Depression In A Community Sample Of 4-Year-Old Children, John Lavigne, Laura Herzing, Edwin Cook, Susan Lebailly, Karen Gouze, Joyce Hopkins, Fred Bryant

Fred B. Bryant

Genetic factors can play a role in the multiple level of analyses approach to understanding the development of child psychology. The present study examined gene-environment correlations and Gene x Environment interactions for polymorphisms of three target genes, the serotonin transporter gene, the D4 dopamine reactor gene, and the monoamine oxidase A gene in relation to symptoms of anxiety, depression, and oppositional behavior. Saliva samples were collected from 175 non-Hispanic White, 4-year-old children. Psychosocial risk factors included socioeconomic status, life stress, caretaker depression, parental support, hostility, and scaffolding skills. In comparison with the short forms (s/s, s/l) of the serotonin transporter …

Eight-Month Test-Retest Agreement In Morning Salivary Cortisol, Self- And Parent-Rated Anxiety In Boys With An Autism Spectrum Disorder, Christopher Sharpley, Vicki Bitsika, Linda Agnew, Nicholas Andronicos

Vicki Bitsika

The agreement over time in morning salivary cortisol concentrations and also self- and parent-rated anxiety was investigated in a sample of 16 boys with an ASD. Cortisol and anxiety data were collected eight months apart. Results indicated that there were significant correlations between each pair of measures from the two occasions, suggesting that cortisol concentrations and anxiety did not vary much at all over that time, challenging the assumption that cortisol needs to be measured over multiple days to obtain reliable data from children with an ASD. Implications for research into the ways these children respond to chronic stressors are …

Psychosocial Moderators Of Perceived Stress, Anxiety And Depression In University Students: An International Study, Aileen Pidgeon, Stephanie Mcgrath, Heide Magya, Peta Stapleton, Barbara Lo

Peta B. Stapleton

Extensive research shows university students experience high levels of stress, which can lead to the development of mental health problems such as anxiety and depression. Preliminary evidence supports the role of psychosocial factors such as perceived social support (PSS) and campus connectedness (CC) as protective factors in the development of mental health problems in university students. However, research conducted on the potential ameliorating effects of social support on stress applying Cohen and Wills’ (1985) stress-buffering hypothesis produced weak, inconsistent, and even contradictory results. In addition, little attention has been given to examining the protective role of CC in the relationships …

Variation In The Profile Of Anxiety Disorders In Boys With An Asd According To Method And Source Of Assessment, Vicki Bitsika, Christopher Sharpley

Vicki Bitsika

To determine any variation that might occur due to the type of assessment and source used to assess them, the prevalence of 7 anxiety disorders were investigated in a sample of 140 boys with an Autism spectrum disorder (ASD) and 50 non-ASD (NASD) boys via the Child and Adolescent Symptom Inventory and the KIDSCID Clinical Interview. Boys with an ASD were significantly more anxious than their NASD peers. Data collected from the boys with an ASD themselves showed differences in the severity and diagnostic criterion of anxiety disorders to data collected from the boys’ parents. There were age-related variations to …

Addressing Distress And Pain In Animal Research: The Veterinary, Research, Societal, Regulatory And Ethical Contexts For Moving Forward, Kathleen Conlee, Martin Stephens, Andrew N. Rowan

Andrew N. Rowan, DPhil

While most people recognize that biomedical scientists are searching for knowledge that will improve the health of humans and animals, the image of someone deliberately causing harm to an animal in order to produce data that may lead to some future benefit has always prompted an uncomfortable reaction outside the laboratory. However, proponents of animal research have usually justified the practice by reference to greater benefits (new knowledge and medical treatments) over lesser costs (in animal suffering and death). Given that one of the costs of animal research is the suffering experienced by the animals, the goal of eliminating distress …

Interactions Of Borderline Personality Disorder And Anxiety Disorders Over Ten Years, Alex S. Keuroghlian,, John G. Gunderson, Maria E. Pagano, John C. Markowitz, Emily B. Ansell, M. Tracie Shea, Leslie C. Morey, Charles A. Sanislow, Carlos M. Grilo, Robert L. Stout, Mary C. Zanarini, Thomas H. Mcglashan, Andrew E. Skodol

Charles A. Sanislow, Ph.D.