Medicine and Health Sciences Commons^™

Practice Effects In A Longitudinal, Multi-Center Alzheimer's Disease Prevention Clinical Trial, Erin L. Abner, Brandon C. Dennis, Melissa J. Mathews, Marta S. Mendiondo, Allison Caban-Holt, Richard J. Kryscio, Frederick A. Schmitt, John J. Crowley

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Practice effects are a known threat to reliability and validity in clinical trials. Few studies have investigated the potential influence of practice on repeated screening measures in longitudinal clinical trials with a focus on dementia prevention. The current study investigates whether practice effects exist on a screening measure commonly used in aging research, the Memory Impairment Screen (MIS).

METHODS: The PREADViSE trial is a clinical intervention study evaluating the efficacy of vitamin E and selenium for Alzheimer's disease prevention. Participants are screened annually for incident dementia with the MIS. Participants with baseline and three consecutive follow-ups who made less …

Cybercycling For Cognitive Health: Comparing Physical Mental And Combined Exercise, Anna Scribner

Honors Theses

Several meta-analyses of randomized controlled trials (RCT) have shown exercise to improve cognitive function in normal aging, mild cognitive impairment (MCI) and dementia (Colcombe & Kramer, 2003, O’ Leary et al., 2011). Cognitive benefit from mental exercise alone is less definitive. A recent RCT (Anderson-Hanley et al., 2012) found greater benefit from three months of virtual-reality enhanced exercise than physical exercise alone among 79 independent living older adults. The current study aimed to replicate this work. In this study, six seniors that either lived or worked at Schaffer Heights were enrolled in the study. Participants were randomized into one of …