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Full-Text Articles in Medicine and Health Sciences
Dietary Fats And Membrane Function: Implications For Metabolism And Disease, Anthony J. Hulbert, Nigel Turner, Leonard H. Storlein, Paul Else
Dietary Fats And Membrane Function: Implications For Metabolism And Disease, Anthony J. Hulbert, Nigel Turner, Leonard H. Storlein, Paul Else
Faculty of Health and Behavioural Sciences - Papers (Archive)
Lipids play varied and critical roles in metabolism, with function dramatically modulated by the individual fatty acid moities in complex lipid entities. In particular, the fatty acid composition of membrane lipids greatly influences membrane function. Here we consider the role of dietary fatty acid profile on membrane composition and, in turn, its impact on prevalent disease clusters of the metabolic syndrome and mental illness. Applying the classical physiological conformer-regulator paradigm to quantify the influence of dietary fats on membrane lipid composition (i.e. where the membrane variable is plotted against the same variable in the environment - in this case dietary …
An Allometric Comparison Of Microsomal Membrane Lipid Composition And Sodium Pump Molecular Activity In The Brain Of Mammals And Birds, Anthony J. Hulbert, Paul Else, Nigel Turner
An Allometric Comparison Of Microsomal Membrane Lipid Composition And Sodium Pump Molecular Activity In The Brain Of Mammals And Birds, Anthony J. Hulbert, Paul Else, Nigel Turner
Faculty of Health and Behavioural Sciences - Papers (Archive)
Previous research has shown that the lipid milieu surrounding membrane proteins may be an important factor in determining their activity. To investigate this we have examined sodium pump molecular activity and microsomal membrane lipid composition in the brain of five mammalian and eight avian species ranging in size from 30 g mice to 280 kg cattle and 13 g zebra finches to 35 kg emus, respectively. Sodium pump (Na+,K+-ATPase) activity was higher in the smaller species and showed a significant allometric decline with body mass in both the mammals (μmol Pi h-1 mg wet …