Medicine and Health Sciences Commons^™

Analyzing Pre-Operative Hospital Stay And Incidence Of Hospital Acquired Infection: A Retrospective Study, Maria Costantino, Ornella Piazza, Enrico Coscioni, Emilia Anna Vozzella, Walter Longanella, Francesco De Caro

Translational Medicine @ UniSa

Background: Healthcare-associated infections (HCAIs) pose a significant challenge, impacting patient safety and treatment effectiveness. This retrospective study investigates the correlation between preoperative hospital stays and HCAIs in ICU cardiac surgery patients. Methods: Medical records of 35 patients who died post-cardiac surgery in the ICU were analyzed, focusing on the duration of preoperative hospitalization. Results: Prolonged preoperative stays strongly correlate (r=0.993) with increased HCAIs, indicating a critical risk factor. Conclusions: The duration of preoperative hospital stays is pivotal in HCAI risk. Prospective multicenter studies are needed for validation, which is crucial for enhancing patient safety and treatment efficacy.

Invasive And Non-Invasive Assessment Of Non-Culprit Coronary Lesions In Patients With St-Segment Elevation Myocardial Infarction, Germano Junior Ferruzzi, Michele Bellino, Angelo Silverio, Marco Di Maio, Mariagiovanna Vassallo, Carmine Vecchione, Gennaro Galasso

Translational Medicine @ UniSa

The angiographic evidence of coronary multivessel disease (MVD) increases significantly the risk of recurrent ischemic events in patients with ST-segment elevation myocardial infarction (STEMI). Recent evidence suggests that a complete revascularization strategy should be considered the standard of care in these patients and performed for significant non-culprit lesions (NCLs) after careful assessment of the individual risk-benefit ratio. However, the optimal timing and the modality for the assessment of NCLs is not fully standardized. This brief review aims to summarise the management of MVD in patients with STEMI and to provide an overview of the principal techniques used to guide revascularisation …

Telerehabilitation: A Solution For Patients After Hip Fracture?, Alessia Bramanti, Rossella Ciurleo, Carmine Vecchione, Andrea Turolla, Noemi Piramide, Michele Ciccarelli, Erica Piramide, Marina Garofano

Translational Medicine @ UniSa

Hip fracture is the most common cause of hospitalization in frail geriatric subjects due to osteoporosis and recurrent falls. The clinical practice guidelines for rehabilitation after surgery in patients with hip fractures recommend to start treatment early. However, the outbreak of SARS-CoV-2 pandemic between December 2019 and January 2020 forced to lockdown. Thus, telerehabilitation seemed the best solution to remote assistance. In this scenario, the aim of our study is to assess the effects of telerehabilitation and to clarify and rearrange the knowledge about its usability and feasibility in patients after hip fracture in emergency conditions, such as the pandemic …

Sex And Gender In Ageing And Longevity: Highlights From An International Course, Giuseppina Candore, Giulia Accardi, Anna Aiello, Giovannella Baggio, Tiziana Bellini, Vittorio Calabrese, Anna Paola Carreca, Ignazio Carreca, Anna Masucci, Monica Cattaneo, Serena Dato, Danilo Di Bona, Luca Fabris, Caterina Gambino, Gabriele Di Lorenzo, Claudio Franceschi, Mattia Emanuela Ligotti, Maria Cristina Manfrinato, Annibale Alessandro Puca, Martina Tamburello, Roberta Vassallo, Calogero Caruso

Translational Medicine @ UniSa

Gender medicine is a multidisciplinary science and represents an important perspective for pathophysiological and clinical studies in the third millennium. Here, it is provided an overview of the topics discussed in a recent course on the Role of Sex and Gender in Ageing and Longevity. The paper highlights three themes discussed in the course, i.e., the interaction of gender/sex with, i) the pathophysiology of age-related diseases; ii), the role of genetics and epigenetics in ageing and longevity and, iii) the immune responses of older people to pathogens, vaccines, autoantigens, and allergens. Although largely unexplored, sex and gender are modulators …

Two-Year Opioid Prescription Trends In Local Sanitary Agency Naples 3 South, Campania Region, Italy. Descriptive Analyses And Ai-Based Translational Perspectives, Marco Cascella, Maurizio Capuozzo, Francesco Ferrara, Alessandro Ottaiano, Francesco Perri, Francesco Sabbatino, Valeria Conti, Vittorio Santoriello, Alfonso Maria Ponsiglione, Maria Romano, Francesco Amato, Ornella Piazza

Translational Medicine @ UniSa

Aims: This study delves into the two-year opioid prescription trends in the Local Sanitary Agency Naples 3 South, Campania Region, Italy. The research aims to elucidate prescribing patterns, demographics, and dosage categories within a population representing 1.7% of the national total. Perspectives on artificial intelligence research are discussed.

Methods: From the original dataset, spanning from January 2022 to October 2023, we processed multiple variables including demographic data, medications, dosages, drug consumption, and administration routes.

Results: The analysis reveals a conservative approach to opioid therapy. In subjects under the age of 20, prescriptions accounted for 2.1% in 2022 and declined to …

Allergic Diseases In The Elderly, Gabriele Di Lorenzo, Marcello Melluso, Alessandro Rodolico, Aurelio Seidita

Translational Medicine @ UniSa

Recent increases in allergic diseases are thought to be caused by better hygiene, Westernized diets, air pollution, climate change, and other factors that influence host microbiota, a key player in the induction and maintenance of immunoregulatory circuits and tolerance. The increase of allergic diseases in the elderly is also related to additional factors, such as various comorbidities that may interfere with the development and the type of allergic reactions. Immunosenescence plays a central role in these reactions, altering microbiota responses and triggering inflammageing. In addition, in the elderly, there is a shift from Th1 to Th2 immunity, thus favoring allergic …

Redoxomics In Ageing And Neurodegenerative Disorders: From Bench To Clinics, Vittorio Calabrese, Ursula M. Jacob, Tilman Fritsch, Noemi Osakabe

Translational Medicine @ UniSa

There is no abstract for this article type.

Scale Of Assessment Of Caregiver Care Burden Of People With Dementia: A Systematic Review Of Literature, Veronica Strini, Angela Prendin, Valentina Cerrone, Roberta Schiavolin, Ilaria De Barbieri, Vincenzo Andretta, Luigi Fortino, Biagio Santella, Gianluigi Franci, Mario Capunzo, Giovanni Boccia

Translational Medicine @ UniSa

Cases of dementia have increased significantly in recent years. The family represents the main cornerstone of assistance to the elderly suffering from dementia, in particular the caregiver. Family members who take on the role of caregiver are subjected to physical, psychological, emotional, social and financial stress, which can be conceptualised with the term “burden”. The aim of this study was to investigate which tools are best suited to measure the type of burden based on the type of dementia for each caregiver. A literature search was undertaken in MEDLINE, CINHAL and The Cochrane Database in September 2022, including articles from …