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Time-Dependent Ghrelinergic Signaling And Hyperphagia Induced By Olanzapine, Q Zhang, M He, J Lian, C Deng, Xu-Feng Huang
Time-Dependent Ghrelinergic Signaling And Hyperphagia Induced By Olanzapine, Q Zhang, M He, J Lian, C Deng, Xu-Feng Huang
Qingsheng Zhang
Olanzapine is widely used to treat schizophrenia and other mental diseases. Interestingly, although increased body weight is evident throughout the course of olanzapine treatment, elevated food intake only appears in relatively shorter term. Olanzapine can modulate ghrelin levels, which may upregulate neuropeptide Y (NPY) secretion at hypothalamus. Brain-specific homeobox transcription factor (BSX) may also be involved in ghrelin-induced hyperphagia. PURPOSE: To investigate the effect of olanzapine on central NPY, BSX and plasma ghrelin levels, and their relationship to food intake. METHODS: Rats were treated with olanzapine (1mg/kg, orally, 3x/day, n=12/group) or vehicle for 1 week, 2 weeks, or 5 weeks. …
Time-Dependant Alterations Of Hypothalamic Energy Regulatory Network By Olanzapine In Rats, Q Zhang, M He, Hongqin Wang, J Lian, C Deng, Xu-Feng Huang
Time-Dependant Alterations Of Hypothalamic Energy Regulatory Network By Olanzapine In Rats, Q Zhang, M He, Hongqin Wang, J Lian, C Deng, Xu-Feng Huang
Qingsheng Zhang
Abstract of a paper that presented at the Australian Neuroscience Society 32nd Annual meeting.