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Full-Text Articles in Medicine and Health Sciences
The Role Of Brn-3.2 In Retinal Ganglion Cell Differentiation, Jerin Marie Wright
The Role Of Brn-3.2 In Retinal Ganglion Cell Differentiation, Jerin Marie Wright
Loma Linda University Electronic Theses, Dissertations & Projects
Within the retina, the POU domain of transcription factors brn-3.0, brn-3.1, and brn-3.2 are present only in retinal ganglion cells. These genes are believed to be involved in establishing neural cell lineages in mammals. In this study brn-3.2 was examined by comparing the number of ganglion cells present during postnatal development in normal mice (+/+), in mice homozygous (-/-) for the brn-3.2 gene, and in adult mice with a heterozygous gene deletion (+/-) for brn-3.2. Optic nerve cross sections were imaged by electron microscopy, and axon profiles counted systematically by hand. These counts were then related to the nerve cross …
Neuronal And Metabolic Increases In Pedunculopontine Nucleus Of Parkinson's Rats, Jonathan Dennis Carlson
Neuronal And Metabolic Increases In Pedunculopontine Nucleus Of Parkinson's Rats, Jonathan Dennis Carlson
Loma Linda University Electronic Theses, Dissertations & Projects
The theoretical mechanisms underlying the symptoms of Parkinson’s disease are based on dysfunctional output from the basal ganglia projected to the cortex via the thalamus. However, the subthalamic nucleus (STN) and substantia nigra pars reticularis (SNr) as part of the basal ganglia, also project to the brainstem, in particular to the pedunculopontine nucleus (PPN). Both the STN and SNr have altered neuronal activity in the 6-hydroxydopamine (6-OHDA) Parkinson’s model rat. Thus, it is hypothesized that the PPN is altered in this model of Parkinson’s disease.
This hypothesis was examined by comparing the rates of glucose metabolism and spontaneous neuronal activity …
Effect Of Obturation And / Or Coronal Seal On The Success Of Root Canal Therapy : An In Vivo Histologic Investigation, Douglas Snider
Effect Of Obturation And / Or Coronal Seal On The Success Of Root Canal Therapy : An In Vivo Histologic Investigation, Douglas Snider
Loma Linda University Electronic Theses, Dissertations & Projects
Numerous studies have examined coronal leakage with in vitro protocols. A search of the literature showed the absence of a long term in vivo, histologic study, examining the effect of coronal and/or radicular leakage on periradicular health.
The purpose of this study was to evaluate the effect of obturation and / or coronal seal in preventing the formation of periradicular lesions in dogs over time. The study was conducted on six beagle dogs. Premolars were cleaned and shaped. Sixteen roots in each dog were randomly assigned to one of four treatment groups of equal size. Group one was obturated using …