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Serotonin Syndrome In Acute Transverse Myelitis: A Casereport, Pei-Chun Hsieh, Jo-Tong Chen, Ta-Shen Kuan, Shu-Min Chen

Rehabilitation Practice and Science

Numerous serotonergic drugs have been increasingly used in recent years to treat depression, pain, insomnia and obesity. However, concomitant use of these drugs may cause serotonin syndrome. The three main clinical features of serotonin syndrome are neuromuscular abnormalities, autonomic hyperactivity, and mental status changes. A wide variety of the clinical presentations range from: very mild symptoms such as tremor, diarrhea, muscle rigidity, or clonus, and hyperreflexia; to fatal consequences such as disseminated intravascular coagulation or multiple-organ failure. Symptoms resolve spontaneously after prompt discontinuation of the precipitating medication. The diagnosis is based on clinical presentation, history of medication, and resolution after …