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Low Intensity, High Frequency Vibration Training To Improve Musculoskeletal Function In A Mouse Model Of Duchenne Muscular Dystrophy, Susan A. Novotny, Tara L. Mader, Angela G. Greising, Angela S. Lin, Robert Guldberg, Gordon L. Warren, Dawn A. Lowe

Physical Therapy Faculty Publications

The objective of the study was to determine if low intensity, high frequency vibration training impacted the musculoskeletal system in a mouse model of Duchenne muscular dystrophy, relative to healthy mice. Three-week old wildtype (n = 26) and mdx mice (n = 22) were randomized to non-vibrated or vibrated (45 Hz and 0.6 g, 15 min/d, 5 d/wk) groups. In vivo and ex vivo contractile function of the anterior crural and extensor digitorum longus muscles, respectively, were assessed following 8 wks of vibration. Mdx mice were injected 5 and 1 days prior to sacrifice with Calcein and Xylenol, respectively. Muscles …