Medicine and Health Sciences Commons^™

Effect Of Celecoxib On Hemophilic Arthropathyof Knee Joint With Synovitis, Ching-Yueh Lin, Chih-Ya Chang, Ming-Jen Ke, Yin-Yin Wu, Yung-Tsan Wu, Yeu-Chin Chen, Tsung-Ying Li

Rehabilitation Practice and Science

Introduction: Recurrent hemoarthrosis leads to synovitis, bone erosion, and subsequent hemoarthropathy in hemophilia. Few clinical trials have focused on the efficacy and adverse effects of nonsteroidal antiinflammatory drugs (NSAIDs), specifically cyclooxygenase-2-selective NSAIDs, in treating hemoarthropathy in patients with hemophilia. This study investigated the effect and safety of celecoxib in treating hemophilic arthropathy with synovitis. Materials and method: A total of 15 patients with hemophilic arthropathy were prescribed 200 mg of celecoxib twice per day for 30 days. Out come measurements regarding before and after treatment, joint range of motion, pain score (visual analogue scale), bleeding frequency, synovial thickness measured using …