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Full-Text Articles in Medicine and Health Sciences
Study Protocol: Investigating The Effects Of Uncarboxylated Osteocalcin And Anodal Trans-Spinal Direct Current Stimulation On Recovery Post-Spinal Cord Injury In Mouse Model, Wing To Ip, Parth Shah, Brandon Nam
Study Protocol: Investigating The Effects Of Uncarboxylated Osteocalcin And Anodal Trans-Spinal Direct Current Stimulation On Recovery Post-Spinal Cord Injury In Mouse Model, Wing To Ip, Parth Shah, Brandon Nam
Student Theses
Individuals with spinal cord injury often present with severe neuromuscular spasticity due to over-secretion of the neurotransmitter known as gamma-aminobutyric acid (GABA). Spasticity is made worse by the other sequelae of SCI, including muscle atrophy and loss of bone mineral density. This manuscript presents a study protocol that attempts to target such widespread physiological changes affecting multiple body systems. Our protocol establishes a potential treatment approach for SCI by combining recent advances in literature with a novel approach never seen before. We hypothesize
that the use of the already-promising anodal trans-spinal direct current stimulation (A- TSDCS) along with exogenous administration …
Paired Associative Transspinal And Transcortical Stimulation Produces Bidirectional Plasticity Of Human Cortical And Spinal Motor Pathways, Luke Dixon, Mohamed Ibrahim, Danielle Santora
Paired Associative Transspinal And Transcortical Stimulation Produces Bidirectional Plasticity Of Human Cortical And Spinal Motor Pathways, Luke Dixon, Mohamed Ibrahim, Danielle Santora
Dissertations, Theses, and Capstone Projects
Anatomical, physiological, and functional connectivity exists between primary motor cortex (M1) and spinal cord neurons. Paired associative stimulation (PAS) produces enduring changes in M1 based on the Hebbian principle of associative plasticity. The present study aims to discover immediate neurophysiological changes on human corticomotor pathways by pairing noninvasive transspinal and transcortical stimulation via transcranial magnetic stimulation (TMS). We delivered paired transspinal and transcortical stimulation for 40-min at precise interstimulus intervals with TMS being delivered after (transspinal-transcortical PAS) or before (transcortical-transspinal PAS) transspinal stimulation. Transspinal-transcortical PAS markedly decreased intracortical inhibition, increased intracortical facilitation and M1 excitability with concomitant decreases of motor …