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Full-Text Articles in Medicine and Health Sciences
Abobotulinumtoxina Efficacy And Safety In Children With Upper Limb Spasticity Previously Treated With Botulinum Toxin, Edward Dabrowski, Mauricio R. Delgado, Joyce Oleszek, Nigar Dursun, Jorge Carranza Del-Rio, Marcin Bonikowski, Benjamin Regnault, Simon Page, Ann Tilton
Abobotulinumtoxina Efficacy And Safety In Children With Upper Limb Spasticity Previously Treated With Botulinum Toxin, Edward Dabrowski, Mauricio R. Delgado, Joyce Oleszek, Nigar Dursun, Jorge Carranza Del-Rio, Marcin Bonikowski, Benjamin Regnault, Simon Page, Ann Tilton
Conference Presentation Abstracts
Introduction: Primary endpoint analysis of this phase 3 study confirmed abobotulinumtoxinA (aboBoNT-A 8 U/kg and 16 U/kg) significantly reduced hypertonia versus the 2 U/kg low-dose control and was generally well tolerated (Delgado, et al, 2021). However, the impact of previous botulinum neurotoxin (BoNT) injections on treatment outcomes remains largely unexplored.
Methods: We present subgroup analyses of a phase 3 study conducted in children (aged 2-17) with cerebral palsy (Gross Motor Function Classification System [GMFCS] Levels I-IV) and spasticity in ≥1 upper limb. In the first treatment cycle, 210 children were randomized to treatment with aboBoNT-A 2 U/kg, 8 U/kg or …