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Animal experiment; animal model; animal tissue; antineoplastic activity; article; breast cancer; cancer chemotherapy; cancer size; cancer tissue; cell proliferation; cell strain MCF 7; contrast enhanced ultrasound; contrast enhancement; controlled study; drug efficacy; drug response; echography; female; histopathology; human; human cell; image analysis; immunohistochemistry; liver parenchyma; microvascular density; mouse; nonhuman; oncological parameters; tissue perfusion; tumor cell density; tumor vascularization; tumor xenograft; ultrasound transducer
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Full-Text Articles in Medicine and Health Sciences
Assessment Of Early Tumor Response To Cytotoxic Chemotherapy With Dynamic Contrast-Enhanced Ultrasound In Human Breast Cancer Xenografts., Jian-Wei Wang, Wei Zheng, Ji-Bin Liu, Yao Chen, Long-Hui Cao, Rong-Zhen Luo, An-Hua Li, Jian-Hua Zhou
Assessment Of Early Tumor Response To Cytotoxic Chemotherapy With Dynamic Contrast-Enhanced Ultrasound In Human Breast Cancer Xenografts., Jian-Wei Wang, Wei Zheng, Ji-Bin Liu, Yao Chen, Long-Hui Cao, Rong-Zhen Luo, An-Hua Li, Jian-Hua Zhou
Department of Radiology Faculty Papers
There is a strong need to assess early tumor response to chemotherapy in order to avoid adverse effects from unnecessary chemotherapy and allow early transition to second-line therapy. This study was to quantify tumor perfusion changes with dynamic contrast-enhanced ultrasound (CEUS) in the evaluation of early tumor response to cytotoxic chemotherapy. Sixty nude mice bearing with MCF-7 breast cancer were administrated with either adriamycin or sterile saline. CEUS was performed on days 0, 2, 4 and 6 of the treatment, in which time-signal intensity (SI) curves were obtained from the intratumoral and depth-matched liver parenchyma. Four perfusion parameters including peak …