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Full-Text Articles in Medicine and Health Sciences
Soy Isoflavone Reduces Lps-Induced Acute Lung Injury Via Increasing Aquaporin 1 And Aquaporin 5 In Rats, Xiaobo Wang, Yili Zhang, Xiuyun Zhou, Xiumei Xia, Weijun Teng, Lin Sheng, Jing Ding
Soy Isoflavone Reduces Lps-Induced Acute Lung Injury Via Increasing Aquaporin 1 And Aquaporin 5 In Rats, Xiaobo Wang, Yili Zhang, Xiuyun Zhou, Xiumei Xia, Weijun Teng, Lin Sheng, Jing Ding
Journal Articles
Acute lung injury (ALI) followed with severe inflammation and oxidative stress. Anti-inflammatory and antioxidant are the properties of aquaporin 1 (AQP1) and aquaporin 5 (AQP5). The goal of this study was to see if soy isoflavone can diminish lipopolysaccharide (LPS)-induced ALI and the underling mechanism. LPS-induced ALI was given to Sprague-Dawley rats 14 days following oophorectomy. One hour before the LPS challenge, estradiol (1 mg/kg) was administered subcutaneously as positive control and soy isoflavone was intragastric administration for 14 days prior to LPS challenge with different doses. Six hours after LPS challenge, the pulmonary edema, pathophysiology, inflammation, and the oxidative …