Medicine and Health Sciences Commons^™

Concentration-Dependent Effects Of A Dietary Ketone Ester On Components Of Energy Balance In Mice, Sarah E. Deemer, Rachel A. Davis, Barbara A. Gower, Andrew P. Koutnik, Angela M. Poff, Stephanie L. Dickinson, David B. Allison, Dominic P. D'Agostino, Eric P. Plaisance

Faculty Publications

Exogenous ketones may provide therapeutic benefit in treatment of obesity. Administration of the ketone ester (KE) R,S-1,3-butanediol acetoacetate diester (BD-AcAc) decreases body weight in mice, but effects on energy balance have not been extensively characterized. The purpose of this investigation was to explore concentration-dependent effects of BD-AcAc on energy intake and expenditure in mice. Forty-two male C57BL/6J mice were randomly assigned to one of seven isocaloric diets ( = 6 per group): (1) Control (CON, 0% KE by kcals); (2) KE5 (5% KE); (3) KE10 (10% KE); (4) KE15 (15% KE); (5) KE20 (20% KE); (6) KE25 (25% KE); and …

Validity Of Estimating Minute-By-Minute Energy Expenditure Of Continuous Walking Bouts By Accelerometry, Erin E. Kuffel, Scott E. Crouter, Jere D. Haas, Edward A. Frongillo Jr., David R. Bassett Jr

Faculty Publications

Background: Objective measurement of physical activity remains an important challenge. For wearable monitors such as accelerometer-based physical activity monitors, more accurate methods are needed to convert activity counts into energy expenditure (EE).

Purpose: The purpose of this study was to examine the accuracy of the refined Crouter 2-Regression Model (C2RM) for estimating EE during the transition from rest to walking and walking to rest. A secondary purpose was to determine the extent of overestimation in minute-by-minute EE between the refined C2RM and the 2006 C2RM.

Methods: Thirty volunteers (age, 28 ± 7.7 yrs) performed 15 minutes of seated rest, 8 …