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Full-Text Articles in Medicine and Health Sciences
Quantification Of Hormesis In Anticancer-Agent Dose-Responses, Marc A. Nascarella, Edward J. Stanek, George R. Hoffmann, Edward J. Calabrese
Quantification Of Hormesis In Anticancer-Agent Dose-Responses, Marc A. Nascarella, Edward J. Stanek, George R. Hoffmann, Edward J. Calabrese
Edward J. Stanek
Quantitative features of dose responses were analyzed for 2,189 candidate anticancer agents in 13 strains of yeast (Saccharomyces cerevisiae). The agents represent a diverse class of chemical compounds including mustards, other alkylating agents, and antimetabolites, inter alia. Previous analyses have shown that the responses below the toxic threshold were stimulatory and poorly predicted by a threshold dose-response model, while better explained by a hormetic dose-response model. We determined the quantitative features of the hormetic concentration-responses (n = 4,548) using previously published entry and evaluative criteria. The quantitative features that are described are: (1) the width of the concentration range showing …
Feasibility And Acceptability Of Continuous Glucose Monitoring And Accelerometer Technology In Exercising Individuals With Type 2 Diabetes, Nancy Allen, Cynthia Jacelon, Stuart Chipkin
Feasibility And Acceptability Of Continuous Glucose Monitoring And Accelerometer Technology In Exercising Individuals With Type 2 Diabetes, Nancy Allen, Cynthia Jacelon, Stuart Chipkin
Stuart R. Chipkin
Aims and Objectives—The aim of this study was to develop role model data for an intervention to motivate non-exercising individuals with type 2 diabetes mellitus to engage in regular physical activity. Toward that end, the study 1) described Continuous Glucose Monitoring System data and obtained role model CGMS graphs, 2) described a monitor to measure exercise amount and intensity and 3) explored participants’ experiences of the monitors and perceptions of the glucose monitoring data. Background—Physical activity is a cornerstone of diabetes treatment yet the majority of individuals with diabetes are inactive. Thus, increasing physical activity in these individuals demands innovative …
A Photovoice Participatory Evaluation Of A School Gardening Program Through The Eyes Of Fifth Graders, Catherine Sands, Krista Harper, Lee Ellen Reed, Maggie Shar
A Photovoice Participatory Evaluation Of A School Gardening Program Through The Eyes Of Fifth Graders, Catherine Sands, Krista Harper, Lee Ellen Reed, Maggie Shar
Krista M. Harper
In the springtime, fifth grade students at the Williamsburg Elementary School in rural Western Massachusetts ask to snack on sorrel and chives from the school garden, between planting potatoes and building a shade structure for their outdoor classroom. They are members of the first cohort of the curriculum-integrated program initiated by Fertile Ground, a grassroots organization in western Massachusetts. The children’s delight in the fresh greens they have grown marks a national phenomenon: the farm-to-school movement. With limited resources, parents, teachers, students, administrators, and community activists are developing inroads to better school food and food education, by constructing school teaching …
Tree-Based Methods For Discovery Of Association Between Flow Cytometry Data And Clinical Endpoints, M. Eliot, L. Azzoni, C. Firnhaber, W. Stevens, D. K. Glencross, I. Sanne, L. J. Montaner, Andrea S. Foulkes
Tree-Based Methods For Discovery Of Association Between Flow Cytometry Data And Clinical Endpoints, M. Eliot, L. Azzoni, C. Firnhaber, W. Stevens, D. K. Glencross, I. Sanne, L. J. Montaner, Andrea S. Foulkes
Andrea S Foulkes
We demonstrate the application and comparative interpretations of three tree-based algorithms for the analysis of data arising from flow cytometry: classification and regression trees (CARTs), random forests (RFs), and logic regression (LR). Specifically, we consider the question of what best predicts CD4 T-cell recovery in HIV-1 infected persons starting antiretroviral therapy with CD4 count between 200 and 350 cell/μL. A comparison to a more standard contingency table analysis is provided. While contingency table analysis and RFs provide information on the importance of each potential predictor variable, CART and LR offer additional insight into the combinations of variables that together are …