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Full-Text Articles in Medicine and Health Sciences
Effects Of Low-Dose Aspirin In In-Vitro Fertilization, Enrique F. Schisterman, Audrey J. Gaskins, Brian W. Whitcomb
Effects Of Low-Dose Aspirin In In-Vitro Fertilization, Enrique F. Schisterman, Audrey J. Gaskins, Brian W. Whitcomb
Brian W. Whitcomb
Purpose of review—In theory, use of aspirin in IVF is based on its anti-inflammatory, vasodilatory, and platelet aggregation inhibition properties, which improve blood flow to a woman's implantation site. It is hypothesized that this effect on blood flow will improve success rates. Recent findings—Clinical studies investigating the use of low-dose aspirin (LDA) as an adjuvant therapy to IVF have produced conflicting results. The conflicting results have come as a consequence of the heterogeneous mixture of clinical trials with lack of adequate power. Even after multiple metaanalyses, differing estimates of effect were calculated as to whether aspirin should be used in …
Microdose Follicular Flare: A Viable Alternative For Normal Responding Patients Undergoing In Vitro Fertilization?, Eric D. Levensa, Brian W. Whitcomb, Jonathan D. Kortc, Donna Materia-Hoovere, Frederick W. Larsena
Microdose Follicular Flare: A Viable Alternative For Normal Responding Patients Undergoing In Vitro Fertilization?, Eric D. Levensa, Brian W. Whitcomb, Jonathan D. Kortc, Donna Materia-Hoovere, Frederick W. Larsena
Brian W. Whitcomb
Objective—To compare cycle outcomes among normal responding patients ≤30 years receiving microdose follicular flare (MDF) and long-luteal agonist (LL). Design—Retrospective cohort study. Setting—Military-based ART center. Patients—First, autologous ART cycles among 499 women ≤30 years old from 01/1999 to 12/2005. Interventions—Following OCP administration prior to cycle start, patients were non-randomly assigned to either LL or MDF for LH surge suppression. LL received 1 mg/d leuprolide acetate (LA) on cycle day 21, which was reduced to 0.25 mg/day 10–14 days later. MDF received LA (40 μg BID) beginning 3 days after discontinuing OCPs. Both groups received a combination of hMG and rFSH. …
Ovarian Follicular Flushing Among Low Responding Art Patients, Eric D. Levens, Brian W. Whitcomb, Mark D. Payson, Frederick W. Larsen
Ovarian Follicular Flushing Among Low Responding Art Patients, Eric D. Levens, Brian W. Whitcomb, Mark D. Payson, Frederick W. Larsen
Brian W. Whitcomb
A randomized comparison trial was performed to evaluate whether follicular reaspiration with use of a double-lumen retrieval needle improves oocyte recovery when compared with direct follicular aspiration among low-responding patients undergoing ART. There were no differences observed in the number of oocytes retrieved (single lumen: 6.5 +/- 2.2 oocytes, double lumen: 7.2 +/- 2.3 oocytes) whereas follicular reaspiration with the double-lumen retrieval needle resulted in a twofold increase in procedure time.
Z-Scores And The Birthweight Paradox, Enrique F. Schisterman, Brian W. Whitcomb, Sunni L. Mumford, Robert W. Platt
Z-Scores And The Birthweight Paradox, Enrique F. Schisterman, Brian W. Whitcomb, Sunni L. Mumford, Robert W. Platt
Brian W. Whitcomb
Investigators have long puzzled over the observation that low-birthweight babies of smokers tend to fare better than low-birthweight babies of non-smokers. Similar observations have been made with regard to factors other than smoking status, including socio-economic status, race and parity. Use of standardised birthweights, or birthweight z-scores, has been proposed as an approach to resolve the crossing of the curves that is the hallmark of the so-called birthweight paradox. In this paper, we utilise directed acyclic graphs, analytical proofs and an extensive simulation study to consider the use of z-scores of birthweight and their effect on statistical analysis. We illustrate …