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Full-Text Articles in Medicine and Health Sciences

Shifting From Hypofractionated To "Conventionally" Fractionated Thoracic Radiotherapy: A Single Institution's 10-Year Experience In The Management Of Limited-Stage Small-Cell Lung Cancer Using Concurrent Chemoradiation, Gregory Videtic, Pauline Truong, A. Dar, Edward Yu, Larry Stitt Oct 2003

Shifting From Hypofractionated To "Conventionally" Fractionated Thoracic Radiotherapy: A Single Institution's 10-Year Experience In The Management Of Limited-Stage Small-Cell Lung Cancer Using Concurrent Chemoradiation, Gregory Videtic, Pauline Truong, A. Dar, Edward Yu, Larry Stitt

Edward Yu

PURPOSE: To perform a retrospective review of a single institution's 10-year experience in treating limited-stage small-cell lung cancer (LS-SCLC) with a concurrent chemoradiation regimen modeled after the experimental arm of a randomized National Cancer Institute of Canada trial in which hypofractionated radiotherapy started with cycle 2 of chemotherapy. We then looked at the impact on patient outcomes of changing the RT during the course of the decade to a "conventionally" (2 Gy) fractionated regimen, with a focus on toxicity and survival rates. METHODS AND MATERIALS: Between 1989 and 1999, 215 LS-SCLC patients received six cycles of chemotherapy consisting of cyclophosphamide, …


Diagnosing Patients With Tiredness In General Practice, Jenny Doust Jul 2003

Diagnosing Patients With Tiredness In General Practice, Jenny Doust

Jenny Doust

Trying to sort out which patients have a relatively simple problem that will resolve spontaneously from those that require medical treatment and those that require urgent attention is one of the aspects of general practice that makes it interesting and challenging. Patients who present with tiredness in general practice can have any of a long list of diagnoses ranging from the trivial to the life threatening, and knowing how to determine who has which is an essential skill for competent practice.


Continued Cigarette Smoking By Patients Receiving Concurrent Chemoradiotherapy For Limited-Stage Small-Cell Lung Cancer Is Associated With Decreased Survival, Gregory Videtic, Larry Stitt, A. Dar, Walter Kocha, Anna Tomiak, Pauline Truong, Mark Vincent, Edward Yu Apr 2003

Continued Cigarette Smoking By Patients Receiving Concurrent Chemoradiotherapy For Limited-Stage Small-Cell Lung Cancer Is Associated With Decreased Survival, Gregory Videtic, Larry Stitt, A. Dar, Walter Kocha, Anna Tomiak, Pauline Truong, Mark Vincent, Edward Yu

Edward Yu

PURPOSE: To determine the impact of continued smoking by patients receiving chemotherapy (CHT) and radiotherapy (RT) for limited-stage small-cell lung cancer (LSCLC) on toxicity and survival. PATIENTS AND METHODS: A retrospective review was carried out on 215 patients with LSCLC treated between 1989 and 1999. Treatment consisted of six cycles of alternating cyclophosphamide, doxorubicin, vincristine and etoposide, cisplatin (EP). Thoracic RT was concurrent with EP (cycle 2 or 3) only. Patients were known smokers, with their smoking status recorded at the start of chemoradiotherapy (CHT/RT). RT interruption during concurrent CHT/RT was used as the marker for treatment toxicity. RESULTS: Of …


Fatal Injuries In The United States Involving Respirators, 1984-1995, Anthony Suruda, William Milliken, Dale Stephenson, Richard Sesek Mar 2003

Fatal Injuries In The United States Involving Respirators, 1984-1995, Anthony Suruda, William Milliken, Dale Stephenson, Richard Sesek

Dale J. Stephenson

There is little published information concerning the epidemiology of fatal injuries involving respiratory protection. We compiled a case series from U.S. Occupational Safety and Health Administration investigation reports from 1984 through 1995. For the 12-year period there were 41 incidents resulting in 45 deaths due to asphyxiation or chemical poisoning while wearing a respirator. There were 23 deaths related to airline respirators, 17 deaths involving use of negative pressure (air purifying) respirators, and 5 deaths involving self-contained breathing apparatus. Among the 23 deaths involving airline respirators, 15 were associated with compatible connection couplings for breathable air and inert gases. Three …


Environmental Health In Public Health, R. Konkel, Darryl Barnett, Joe Beck, Worley Johnson Dec 2002

Environmental Health In Public Health, R. Konkel, Darryl Barnett, Joe Beck, Worley Johnson

Steve Konkel

A most intriguing question, and one that leads to many debates both inside and outside of the environmental health field, is a definition of environmental health. The answer given is often tempered by one's political slant (i.e., liberal, moderate, or conservative) and by one's professional training (e.g., public health sanitation, chemistry, nursing, ecology, planning, public administration, etc). Although agreement is needed to effectively address the challenges in the field, disagreement often centers on what constitutes environmental health and even on the name or nickname that should be applied to individuals whose primary focus is on one or many aspects of …


Diagnostic And Management Strategies For Anaemia In Adults, Jenny Doust Dec 2002

Diagnostic And Management Strategies For Anaemia In Adults, Jenny Doust

Jenny Doust

BACKGROUND Anaemia is often an incidental finding or is discovered when patients present with nonspecific symptoms such as tiredness. OBJECTIVE This article presents strategies to identify the cause of anaemia and uses four case studies to illustrate these principles. DISCUSSION Few diagnostic tests can completely rule in or rule out causes of anaemia. This makes the investigation of anaemia complex. An understanding of the limitations of tests in aiding diagnosis is required.


Promoting Better Use Of The Psa Test In General Practice: Randomized Controlled Trial Of Educational Strategies Based On Outreach Visits And Mailout, D Weller, F May, D Rowett, A Esterman, C Pinnock, S Nicholson, Jenny Doust, C Silagy Dec 2002

Promoting Better Use Of The Psa Test In General Practice: Randomized Controlled Trial Of Educational Strategies Based On Outreach Visits And Mailout, D Weller, F May, D Rowett, A Esterman, C Pinnock, S Nicholson, Jenny Doust, C Silagy

Jenny Doust

Background. Prostate-specific antigen (PSA) testing for prostate cancer is controversial. Demand for PSA testing is likely to rise in the UK, Australia and other western countries. Primary care needs to develop appropriate strategies to respond to this demand. Objectives. Our aim was to compare the effectiveness of educational outreach visits (EOVs) and mailout strategies targeting PSA testing in Australian primary care. Methods. A randomized controlled trial was conducted in general practices in southern Adelaide. The main outcome measures at baseline, 6 months and 12 months post-intervention were PSA testing rates and GP knowledge in key areas relating to prostate cancer …