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Host Restriction Phenotypes Of Salmonella Typhi And Salmonella Gallinarum, Lisa Pascopella, Bärbel Raupach, Nafisa Ghori, Denise Monack, Stanley Falkow, P. L. C. Small

Public and Community Health Sciences Faculty Publications

Salmonella typhi and Salmonella gallinarum phenotypes correlated with mouse host restriction have been identified by using in vitro and in vivo systems. S. typhi is capable of entering the murine intestinal epithelium via M cells, as is Salmonella typhimurium, which causes systemic infection in the mouse. But, unlike S. typhimurium, S. typhi does not destroy the epithelium and is cleared from the Peyer’s patches soon after M-cell entry. S. gallinarum appears to be incapable of entering the murine Peyer’s patch epithelium. Our in vitro evidence suggests that S. gallinarum is taken up in murine phagocytic cells by a mechanism different …