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Toxin Genotypes And Plasmid Profiles As Determinants Of Systemic Sequelae In Escherichia Coli 0157:H7 Infections, Stephen Ostroff, Phillip Tarr, Marguerite A. Neill, Jay H. Lewi, Nancy Hargrett-Bean, John M. Kobayashi
Toxin Genotypes And Plasmid Profiles As Determinants Of Systemic Sequelae In Escherichia Coli 0157:H7 Infections, Stephen Ostroff, Phillip Tarr, Marguerite A. Neill, Jay H. Lewi, Nancy Hargrett-Bean, John M. Kobayashi
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In 1987, 93 Escherichia coli 0157:H7 isolates were collected during routine surveillance for this pathogen in the state of Washington. Toxin genotypes and plasmid profiles were correlated with the clinical sequelae of illness in 88 of the 93 patients from whom these strains were isolated. Thirteen plasmid patterns were observed among the 88 tested isolates; four patterns accounted for 82(7o of the isolates. Genetic probing for Shiga-like toxins (SLT) I and II demonstrated the presence of both genes in 67 (76%), SLT I alone in three (3%), and SLT II alone in 18 (20%). The hemolytic uremic syndrome or throm-botic …