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A Case-Only Genome-Wide Association Study Of Gender- And Age-Specific Risk Markers For Childhood Leukemia, Sandeep Kumar Singh
A Case-Only Genome-Wide Association Study Of Gender- And Age-Specific Risk Markers For Childhood Leukemia, Sandeep Kumar Singh
FIU Electronic Theses and Dissertations
Males and age group 1 to 5 years show a much higher risk for childhood acute lymphoblastic leukemia (ALL). We performed a case-only genome-wide association study (GWAS), using the Illumina Infinium HumanCoreExome Chip, to unmask gender- and age-specific risk variants in 240 non-Hispanic white children with ALL recruited at Texas Children’s Cancer Center, Houston, Texas. Besides statistically most significant results, we also considered results that yielded the highest effect sizes. Existing experimental data and bioinformatic predictions were used to complement results, and to examine the biological significance of statistical results.
Our study identified novel risk variants for childhood ALL. The …