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Direct Comparison Of Apremilast And Best Supportive Care Using A Discrete Event Simulation, Zoe Clancy, Pharmd

Master of Science in Applied Health Economics and Outcomes Research Capstone Presentations

Apremilast is compared to best supportive care (BSC), and response to treatment is assessed after a trial period of 16 weeks, which corresponds to the primary efficacy endpoint in the apremilast clinical trials. DES is a technique that is event-based and models a population at the individual level in terms of utility, costs, and resource use. The DES was implemented as a series of input, calculation, and output flowcharts in Arena®. The DES reported an incremental QALY per patient of 0.16 and incremental cost per patient of $17,325. The Markov model reported an incremental QALY of 0.18 and incremental cost …