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Full-Text Articles in Medicine and Health Sciences
Is Living In A Region With High Groundwater Arsenic Contamination Associated With Adverse Reproductive Health Outcomes? An Analysis Using Nationally Representative Data From India, Jessie Pinchoff, Brent Monseur, Sapna Desai, Katelyn Koons, Ruben Alvero, Michelle J Hindin
Is Living In A Region With High Groundwater Arsenic Contamination Associated With Adverse Reproductive Health Outcomes? An Analysis Using Nationally Representative Data From India, Jessie Pinchoff, Brent Monseur, Sapna Desai, Katelyn Koons, Ruben Alvero, Michelle J Hindin
Department of Medicine Faculty Papers
Background: Exposure to groundwater arsenic via drinking water is common in certain geographies, such as parts of India, and causes a range of negative health effects, potentially including adverse reproductive health outcomes.
Methods: We conducted an ecological analysis of self-reported rates of stillbirth, recurrent pregnancy loss, and infertility in relation to groundwater arsenic levels in India. We used a gridded, modeled dataset of the probability of groundwater arsenic exceeding 10 μg/L (World Health Organization drinking water limit) to calculate mean probabilities at the district level (n = 599 districts). A spatial integration approach was used to merge these estimates with …
Association Between Baseline Diastolic Blood Pressure And The Efficacy Of Intensive Vs Standard Blood Pressure-Lowering Therapy, Andrew J Foy, Edward J Filippone, Eric Schaefer, Matt Nudy, Mohammed Ruzieh, Anne-Marie Dyer, Vernon M Chinchilli, Gerald V Naccarelli
Association Between Baseline Diastolic Blood Pressure And The Efficacy Of Intensive Vs Standard Blood Pressure-Lowering Therapy, Andrew J Foy, Edward J Filippone, Eric Schaefer, Matt Nudy, Mohammed Ruzieh, Anne-Marie Dyer, Vernon M Chinchilli, Gerald V Naccarelli
Department of Medicine Faculty Papers
Importance: Low diastolic blood pressure (DBP) has been found to be associated with increased adverse cardiovascular events; however, it is unknown whether intensifying blood pressure therapy in patients with an already low DBP to achieve a lower systolic blood pressure (SBP) target is safe or effective.
Objective: To evaluate whether there is an association of baseline DBP and intensification of blood pressure-lowering therapy with the outcomes of all-cause death and cardiovascular events.
Design, setting, and participants: This cohort study analyzed patients who were randomized to intensive or standard BP control in the Action to Control Cardiovascular Risk in Diabetes-Blood Pressure …