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Erythrocyte Long-Chain Omega-3 Fatty Acid Levels Are Inversely Associated With Mortality And With Incident Cardiovascular Disease: The Framingham Heart Study, William S. Harris, Nathan L. Tintle, Mark R. Etherton, Ramachandran S. Vasan
Erythrocyte Long-Chain Omega-3 Fatty Acid Levels Are Inversely Associated With Mortality And With Incident Cardiovascular Disease: The Framingham Heart Study, William S. Harris, Nathan L. Tintle, Mark R. Etherton, Ramachandran S. Vasan
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Background: The extent to which omega-3 fatty acid status is related to risk for death from any cause and for incident cardiovascular disease (CVD) remains controversial. Objective: To examine these associations in the Framingham Heart Study. Design: Prospective and observational. Setting: Framingham Heart Study Offspring cohort. Measurements: The exposure marker was red blood cell levels of eicosapentaenoic and docosahexaenoic acids (the Omega-3 Index) measured at baseline. Outcomes included mortality (total, CVD, cancer, and other) and total CVD events in participants free of CVD at baseline. Follow-up was for a median of 7.3 years. Cox proportional hazards models were adjusted for …