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The Comorbidity And Temporal Relationship Between Anxiety Disorders, Eating Disorders, And Personality Disorders, Mitchell C. Duross

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Background - Population-level data on the prevalence of comorbidity between anxiety-, eating-, and personality disorders remain relatively unexplored. Additionally, the potential existence of a temporal relationship among these three classes of mental disorder is also of interest.

Methods - Lifetime prevalence of, and temporal relationships among, anxiety-, eating-, and personality disorders were assessed using Part II WHO Composite International Diagnostic Interview data from the National Comorbidity Survey- Replication, a nationally representative household survey (n=5692).

Results - Lifetime prevalence estimates for any anxiety-, eating-, and personality disorder were 59.8%, 2.8%, and 13.5%, respectively, among those diagnosed with at least one core …

The Characterization Of The Neuropathological Consequences Of Plac1 Ablation In A Mutant Mouse Model, Jacob Robert Bourgeois

USF Tampa Graduate Theses and Dissertations

Placenta-specific 1 (Plac1) is an X-linked gene that is essential for normal placental development. Previous studies have shown that Plac1 is also expressed in the fetal brain and paternally imprinted. Its expression in the fetal brain is markedly downregulated immediately after birth. Plac1 ablation predisposes Plac1-null males and X^m-X Hets (inactive maternal allele) to an increased risk of developing lethal postnatal hydrocephalus suggesting a functional role for Plac1 during embryonic development. The objective of this study was to characterize the effect of Plac1 on brain development and postnatal function. In order to address this, a …