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Trends In Toxin Profiles Of Human Shiga Toxin-Producing Escherichia Coli (Stec) O157 Strains, United States, 1996-2008, Molly Maitland Leeper
Trends In Toxin Profiles Of Human Shiga Toxin-Producing Escherichia Coli (Stec) O157 Strains, United States, 1996-2008, Molly Maitland Leeper
Public Health Theses
Shiga toxin-producing E. coli (STEC) cause diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS). All STEC produce one or both of two Shiga toxins, Stx1 and Stx2. STEC strains that produce Stx2 are more strongly associated with HUS than strains that produce Stx1 or both Stx1 and Stx2. Epidemiologic evidence indicates a recent increase in the rate of HUS among STEC outbreaks. The increasing rate of HUS could be explained by a shift in the toxin profiles of STEC strains. The purpose of this study was to examine trends in toxin profiles of human STEC O157 isolates from 1996 to …