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Full-Text Articles in Medicine and Health Sciences
The Transcriptional Response To Oxidative Stress During Vertebrate Development: Effects Of Tert-Butylhydroquinone And 2,3,7,8-Tetrachlorodibenzo-P-Dioxin, Mark E. Hahn, Andrew G. Mcarthur, Sibel I. Karchner, Diana G. Franks, Matthew J. Jenny, Alicia R. Timme-Laragy, John J. Stegeman, Bruce R. Woodin, Michael J. Cipriano, Elwood Linney
The Transcriptional Response To Oxidative Stress During Vertebrate Development: Effects Of Tert-Butylhydroquinone And 2,3,7,8-Tetrachlorodibenzo-P-Dioxin, Mark E. Hahn, Andrew G. Mcarthur, Sibel I. Karchner, Diana G. Franks, Matthew J. Jenny, Alicia R. Timme-Laragy, John J. Stegeman, Bruce R. Woodin, Michael J. Cipriano, Elwood Linney
Alicia R. Timme-Laragy
Oxidative stress is an important mechanism of chemical toxicity, contributing to teratogenesis and to cardiovascular and neurodegenerative diseases. Developing animals may be especially sensitive to chemicals causing oxidative stress. The developmental expression and inducibility of anti-oxidant defenses through activation of NF-E2-related factor 2 (NRF2) affect susceptibility to oxidants, but the embryonic response to oxidants is not well understood. To assess the response to chemically mediated oxidative stress and how it may vary during development, zebrafish embryos, eleutheroembryos, or larvae at 1, 2, 3, 4, 5, and 6 days post fertilization (dpf) were exposed to DMSO (0.1%), tert-butylhydroquinone (tBHQ; 10 µM) …
Newspapers And Newspaper Ink Contain Agonists For The Ah Receptor, Jessica E.S. Bohonowych, Bin Zhao, Alicia R. Timme-Laragy, Dawoon Jung, Richard T. Di Giulio, Michael S. Denison
Newspapers And Newspaper Ink Contain Agonists For The Ah Receptor, Jessica E.S. Bohonowych, Bin Zhao, Alicia R. Timme-Laragy, Dawoon Jung, Richard T. Di Giulio, Michael S. Denison
Alicia R. Timme-Laragy
Ligand-dependent activation of the aryl hydrocarbon receptor (AhR) pathway leads to a diverse array of biological and toxicological effects. The best-studied ligands for the AhR include polycyclic and halogenated aromatic hydrocarbons, the most potent of which is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). However, as new AhR ligands are identified and characterized, their structural and physiochemical diversity continues to expand. Our identification of AhR agonists in crude extracts from diverse materials raises questions as to the magnitude and extent of human exposure to AhR ligands through normal daily activities. We have found that solvent extracts of newspapers from countries around the world stimulate the …
Synergistic Induction Of Ahr Regulated Genes In Developmental Toxicity From Co-Exposure To Two Model Pahs In Zebrafish, Alicia R. Timme-Laragy, Crystal J. Cockman, Cole W. Matson, Richard T. Di Giulio
Synergistic Induction Of Ahr Regulated Genes In Developmental Toxicity From Co-Exposure To Two Model Pahs In Zebrafish, Alicia R. Timme-Laragy, Crystal J. Cockman, Cole W. Matson, Richard T. Di Giulio
Alicia R. Timme-Laragy
Polycyclic aromatic hydrocarbons (PAHs) are pollutants created by the incomplete combustion of carbon, and are increasing in the environment largely due to the burning of fossil fuels. PAHs occur as complex mixtures, and some combinations have been shown to cause synergistic developmental toxicity in fish embryos, characterized by pericardial edema and craniofacial malformations. Previous studies have indicated that in the zebrafish model, this toxicity is mediated by the aryl hydrocarbon receptor 2 (AHR2), and enhanced by inhibition of CYP1A activity. In this study, we further examined this interaction of the model PAH and AHR agonist beta-naphthoflavone (BNF) with and without …