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Full-Text Articles in Medicine and Health Sciences

Discriminative Nursing Care Practices Towards Patients With Opioid Use Disorder In The Hospital Setting: How Knowledge And Social Attitudes Impact Care Delivery, Jeanne Adam Bernier May 2024

Discriminative Nursing Care Practices Towards Patients With Opioid Use Disorder In The Hospital Setting: How Knowledge And Social Attitudes Impact Care Delivery, Jeanne Adam Bernier

Doctoral Dissertations

Discriminative nursing care (DNC) practices towards patients with opioid use disorder (OUD) is a current phenomenon negatively affecting patient care and patient outcomes. It leads to delays in care, insufficient pain control, and feelings of guilt and shame, and it is linked to self-isolation, social isolation, social rejection, and even unemployment and housing disruption which perpetuate a dangerous cycle of inequity that is hard to overcome. In some cases, OUD stigmatization even increases morbidity and mortality rates. OUD stigmatization and discrimination are real problems in today’s health care climate due to the vast number of people affected by OUD and …


Bi-Negativity: An Assessment Of Negativity Surrounding Bisexuality From The Lgbtq+ And Heterosexual Communities, Whitney R. Ford Dec 2023

Bi-Negativity: An Assessment Of Negativity Surrounding Bisexuality From The Lgbtq+ And Heterosexual Communities, Whitney R. Ford

The Confluence

This study was conducted to test the hypothesis that negative attitudes towards bisexual people (bi-negativity) exists within the LGBTQ+ and heterosexual communities and to determine if levels of bi-negativity are higher within the LGBTQ+ group. I administered the Gender-Based Attitudes Towards Bisexuality (GBAB) Scale by Nielsen et al. (2022) to measure bi-negativity using an online survey. The results, obtained from 87 participants who identify as LGBTQ+ and 121 participants who identify as heterosexual between the ages of 18 and 80, support my hypothesis that bi-negativity exists within both groups. However, contrary to my second hypothesis, higher levels of bi-negativity were …


Impact Of Covid-19 On Latinx And Black Communities, Carolina Zuluaga Jun 2023

Impact Of Covid-19 On Latinx And Black Communities, Carolina Zuluaga

Dissertations

This critical literature review project explored the impact of COVID-19 on Latinx and Black communities. According to the Centers for Disease Control and Prevention, as of September 28, 2022, around 16% of COVID-19 cases in the United States were among Latinx people, and 14% of cases were among Black people (Centers for Disease Control and Prevention, 2022). Since COVID-19 began, clinicians have become more conscious of the effects of health disparities within racial and ethnic minorities, which has warranted increased advocacy by educating health and mental health providers and creating and providing resources to these communities and clinicians. The review …


Experiences Of Covid-19-Related Racism And Impact On Depression Trajectories Among Racially/Ethnically Minoritized Adolescents, Sabrina R. Liu, Elysia Poggi Davis, Anton M. Palma, Hal S. Stern, Curt A. Sandman, Laura M. Glynn Feb 2023

Experiences Of Covid-19-Related Racism And Impact On Depression Trajectories Among Racially/Ethnically Minoritized Adolescents, Sabrina R. Liu, Elysia Poggi Davis, Anton M. Palma, Hal S. Stern, Curt A. Sandman, Laura M. Glynn

Psychology Faculty Articles and Research

Purpose

In 2020, racially/ethnically minoritized (REMD) youth faced the “dual pandemics” of COVID-19 and racism, both significant stressors with potential for adverse mental health effects. The current study tested whether short- and long-term trajectories of depressive symptoms from before to during the COVID-19 pandemic differed between REMD adolescents who did and did not endorse exposure to COVID-19-era-related racism (i.e., racism stemming from conditions created or exacerbated by the COVID-19 pandemic).

Methods

A community sample of 100 REMD adolescents enrolled in an ongoing longitudinal study of mental health was assessed before and during the COVID-19 pandemic. Participants were 51% girls, mean …


The Role Of Dentate Gyrus Pituitary Adenylate Cyclase Activating Polypeptide (Pacap) In Contextual Fear Discrimination, Samantha Kelly Moriarty Jan 2023

The Role Of Dentate Gyrus Pituitary Adenylate Cyclase Activating Polypeptide (Pacap) In Contextual Fear Discrimination, Samantha Kelly Moriarty

Graduate College Dissertations and Theses

When dysregulated, neural systems important for fear behaviors can contribute to mental health disorders such as anxiety, phobias, and post-traumatic stress disorder (PTSD). In PTSD, a myriad of symptoms is possible, but a hallmark feature of the disorder is generalizing fear. This occurs when fear is experienced inappropriately in relation to the environment or circumstances. To study this behavior in rodent models, contextual fear conditioning is used. Contextual fear conditioning is a learning theory preparation where rodents are conditioned with an aversive stimulus such as foot-shock in one distinct context (A), while concurrently being exposed to a safe context (B). …


Individual Differences In The Criminogenic Effects Of Discrimination: An Exploration Of The Role Of Impulse Control And Callous-Unemotional Traits, Toni Walker Jun 2022

Individual Differences In The Criminogenic Effects Of Discrimination: An Exploration Of The Role Of Impulse Control And Callous-Unemotional Traits, Toni Walker

LSU Doctoral Dissertations

The association between perceived discrimination and engagement in criminal offending has been well studied, especially in samples of minority (predominantly Black, Hispanic, and Latinx) adolescents. Several theories have been developed (Social Schematic Theory) and adapted (General Strain Theory) in an attempt to explain how harmful, discriminatory experiences may have an effect on an individual’s behavior. There may be variability in how an individual responds to perceived discrimination, however, but the moderating role of personality characteristics has not been explored. Impulse control and callous-unemotional (CU) traits are both established predictors of offending and may also relate to the mechanisms that theories …


Intergenerational Risk And Resilience Pathways From Discrimination And Acculturative Stress To Infant Mental Health, Sabrina R. Liu, Curt A. Sandman, Elyssia Poggi Davis, Laura M. Glynn Mar 2022

Intergenerational Risk And Resilience Pathways From Discrimination And Acculturative Stress To Infant Mental Health, Sabrina R. Liu, Curt A. Sandman, Elyssia Poggi Davis, Laura M. Glynn

Psychology Faculty Articles and Research

Preconception and prenatal stress impact fetal and infant development, and women of color are disproportionately exposed to sociocultural stressors like discrimination and acculturative stress. However, few studies examine links between mothers’ exposure to these stressors and offspring mental health, or possible mitigating factors. Using linear regression, we tested associations between prenatally assessed maternal acculturative stress and discrimination on infant negative emotionality among 113 Latinx/Hispanic, Asian American, Black, and Multiethnic mothers and their children. Additionally, we tested interactions between stressors and potential pre- and postnatal resilience-promoting factors: community cohesion, social support, communalism, and parenting self-efficacy. Discrimination and acculturative stress were related …


Perceived Discrimination As A Moderator Of The Relationship Between Allostatic Load And Asthma Control, Vera Kern Jan 2022

Perceived Discrimination As A Moderator Of The Relationship Between Allostatic Load And Asthma Control, Vera Kern

Walden Dissertations and Doctoral Studies

While asthma prevalence in the United States is generally declining, African Americans tend to experience poorer outcomes regarding asthma severity and control. The purpose of the present study was to test whether discrimination (everyday and lifetime) moderated the relationship between allostatic load and asthma severity/asthma control (dyspnea and peak flow). In previous literature, researchers established the relationship between allostatic load and asthma severity/asthma control among African Americans. The biopsychosocial model and allostatic load theory served as the theoretical frameworks for this study. In this cross-sectional, nonexperimental, quantitative design, 201 African Americans between the ages of 34 and 82 years were …


The Expression Of Satanist Identity: Does Visible Identification Of Satanism Predict Discrimination And Depression?, Allyson Dudley Jan 2022

The Expression Of Satanist Identity: Does Visible Identification Of Satanism Predict Discrimination And Depression?, Allyson Dudley

All Graduate Theses, Dissertations, and Other Capstone Projects

The current research examines the relationship between visible expression of religion, identification within Satanism, experiences of discrimination, and depression in a sample of modern Satanists (n = 1,272). Historically, Satanism has been scrutinized as immoral and a threat to public safety. The current research attempts to challenge that viewpoint by employing culturally competent methods and understanding of modern Satanism. Findings indicate a negative relationship between expression of Satanism and discrimination, expression of Satanism and depressive symptoms, in-group ties and discrimination, and identification (in-group ties and in-group affect) and depressive symptoms. Results show a positive relationship between identification with Satanism and …


Compassion, Discrimination, And Prosocial Behaviors: Young Diasporic Chinese During The Covid-19 Pandemic, Youli Chen, Zicong Wang, Qi Zhang, Weizhen Dong, Jia Huei, Chen Xu, Sizhe Ji Wu, Xiangyang Zhang, Chun Chen Jan 2022

Compassion, Discrimination, And Prosocial Behaviors: Young Diasporic Chinese During The Covid-19 Pandemic, Youli Chen, Zicong Wang, Qi Zhang, Weizhen Dong, Jia Huei, Chen Xu, Sizhe Ji Wu, Xiangyang Zhang, Chun Chen

Community & Environmental Health Faculty Publications

The coronavirus disease 2019 (COVID-19) pandemic has fueled anti-Asian, especially anti-Chinese sentiments worldwide, which may negatively impact diasporic Chinese youths' adjustment and prosocial development. This study examined the association between compassion, discrimination and prosocial behaviors in diasporic Chinese youths during the COVID-19 pandemic. 360 participants participated and completed the multi-country, cross-sectional, web-based survey between April 22 and May 9, 2020, the escalating stage of the pandemic. This study found compassion as prosocial behaviors' proximal predictor, while discrimination independently predicted participation in volunteering, and could potentially enhance the association between compassion and charitable giving. These findings suggest that prosociality among young …


Black And White Health Disparities: Racial Bias In American Healthcare, Yasmeen Almomani Jul 2021

Black And White Health Disparities: Racial Bias In American Healthcare, Yasmeen Almomani

Bridges: An Undergraduate Journal of Contemporary Connections

This paper explores the historical implications of race in American society that have led to implicit racism in the healthcare system. Racial bias in healthcare against Black people is a factor in the health disparities between Black and white people in America, such as the gap in life expectancy, infant death, and maternal mortality. Black people are more likely to report racial discrimination from healthcare providers, which is a reason for the decreased quality of care received. The past justifications of slavery, the Tuskegee syphilis study, and the medical experimentations on Black women are horrifying but were considered acceptable in …


Minority Stress And Alcohol Use In Sexual Minority Women's Daily Lives, Robin J. Lewis, Kelly A. Romano, Sarah J. Ehlke, Cathy Lau-Barraco, Cassidy M. Sandoval, Douglas J. Glenn, Kristin E. Heron Jan 2021

Minority Stress And Alcohol Use In Sexual Minority Women's Daily Lives, Robin J. Lewis, Kelly A. Romano, Sarah J. Ehlke, Cathy Lau-Barraco, Cassidy M. Sandoval, Douglas J. Glenn, Kristin E. Heron

Psychology Faculty Publications

No abstract provided.


A Multifactorial Intervention To Reduce Weight Bias In Healthcare Providers, Rose M. Flinchum May 2020

A Multifactorial Intervention To Reduce Weight Bias In Healthcare Providers, Rose M. Flinchum

Evidence-Based Practice Project Reports

No abstract provided.


Effects Of Latinx Parental English Proficiency On Stress, Maria Alvarez Pineda May 2020

Effects Of Latinx Parental English Proficiency On Stress, Maria Alvarez Pineda

Student Research Posters

In the United States, patients who have Limited English Proficiency (LEP) report having more problems communicating with their children’s doctors (Eneriz-Wieme et al., 2014) and experiencing more discrimination (Zhang et al., 2012) which can lead to increased psychological distress (Torres et al., 2012). The goal of this study was to determine if level of English Proficiency is related to stress levels and discrimination among Latinx parents. Participants consisted of 22 Latinx parents (86.4% Mexican and 90.9% female) in the San Francisco Bay Area. The Acute Stress Appraisals scale (Mendes, et al., 2007) measured parents' stress levels before and after an …


Community Psychology's Impact On Public Health And The Experience Of Marginalization, Katie Hudick Apr 2020

Community Psychology's Impact On Public Health And The Experience Of Marginalization, Katie Hudick

Richard T. Schellhase Essay Prize in Ethics

Vulnerable and marginalized populations face a series of risks and dangers throughout their daily lives. This is not simply limited to explicit forms of discrimination and hatred, but systemic forms of oppression and discrimination which limit those not belonging to more privileged and affluent socioeconomic or sociocultural groups. Community psychology operates as a means of analyzing how environmental and social factors impact specific demographic groups within a larger population and by extension the experience of mental health specific to these groups (Townley, Brown, & Sylvestre, 2018). In the application of this field, it is critical to understand the dynamics of …


Effects Of Latinx Parental English Proficiency On Stress, Maria Alvarez Pineda Jan 2020

Effects Of Latinx Parental English Proficiency On Stress, Maria Alvarez Pineda

Global Public Health | Senior Theses

Background

In the United States, patients who have Limited English Proficiency (LEP) report having more problems communicating with their children’s doctor which leads to these children having worse health care access than those who have parents with a High English Proficiency (HEP). Parents with LEP also experience discrimination in this setting which can lead to increased psychological distress. The goal of this study was to determine if the level of English Proficiency is associated to stress levels and discrimination among Latinx parents when they take their chidlren to the doctor.

Methods

Participants consisted of 22 Latinx parents (86.4% Mexican and …


Well-Being, Discrimination, And Self-Management Among Racialized Lgbq+ Newcomers Living In Waterloo Region, Ontario, Emily Cox Jan 2020

Well-Being, Discrimination, And Self-Management Among Racialized Lgbq+ Newcomers Living In Waterloo Region, Ontario, Emily Cox

Theses and Dissertations (Comprehensive)

Racism and homo/biphobia may negatively impact the well-being of racialized LGBTQ+ newcomers. While current research focuses predominantly on negative aspects of well-being (e.g., distress, exclusion), research on resilience and positive aspects of well-being (e.g., positive affect) is limited. Although self-management strategies (i.e., activities and attitudes to improve one’s well-being) could be a key factor in promoting well-being, previous research has not addressed how racialized LGBTQ+ newcomers use self-management strategies. Further, there is limited research about the role service providers (e.g., settlement services, mental and physical health services) play in supporting these strategies. In this study, eight racialized LGBQ+ newcomers and …


Cultural Correlates Of Ptsd In Latinos Residing In The U.S., Gabriela A. Nagy Aug 2017

Cultural Correlates Of Ptsd In Latinos Residing In The U.S., Gabriela A. Nagy

Theses and Dissertations

The present study examined the associations between cultural variables (i.e., acculturative stress, discrimination, social support, migration planning, and reasons for migrating) and exposure to trauma and PTSD in a sample of Latinos (N=2,554) residing in the United States, who participated in the National Latino and Asian America Study (NLAAS). Results showed that there were significant positive associations between trauma exposure and migrating because of political reasons, migrating in search of medical attention, migrating due to

marital or family problems, and forced migration, suggesting they may be risk factors for being exposed to trauma. There was a negative association between trauma …


Exploring Proximal And Distal Psychosocial Stressors Influencing The Health Outcomes Of Urban American Indians In The Midwest, Alina Aloma Aug 2016

Exploring Proximal And Distal Psychosocial Stressors Influencing The Health Outcomes Of Urban American Indians In The Midwest, Alina Aloma

Theses and Dissertations

Researchers have theorized that colonization and forced assimilation of American Indians/Alaska Natives (AI/AN) in the U.S. are associated with the current health outcomes of AI/AN groups. The literature has begun to link a number of negative health outcomes such as chronic illnesses, substance abuse, grief, depression, and anxiety with distal stressors associated with historical loss, as well as with proximal stressors that are continued reminders of historical trauma such as present day discrimination. The present study utilized a quantitative methodology along with a community informed framework through collaboration with multiple urban AI/AN-serving agencies in a metropolitan area of the Midwest …


South Asian Women's Sexual Relationship Power: Examining The Role Of Sexism, Cultural Values Conflict, Discrimination, And Social Support, Chandni D. Shah Aug 2016

South Asian Women's Sexual Relationship Power: Examining The Role Of Sexism, Cultural Values Conflict, Discrimination, And Social Support, Chandni D. Shah

Open Access Dissertations

The lack of literature examining sexual experiences of South Asian women in dating relationships has important implications for the healthy development of long lasting romantic relationships. It is important to understand South Asian women’s relationship experiences in the context of power and sexism (interpersonal power framework; Pulerwitz, Gortmaker, & DeJong, 2000) and the role of specific sociopolitical factors (e.g., discrimination). Understanding South Asian women’s experiences of power in a sociopolitical context will help professionals when working with them to develop healthier sexual relationships through therapy outreach, and community programming. I used a correlational, quantitative study to examine the associations between …


Have You Hugged A Soldier Today? Veterans Struggle With Invisible Wounds Of War From Vietnam To Afghanistan, Gabe Mora Jun 2014

Have You Hugged A Soldier Today? Veterans Struggle With Invisible Wounds Of War From Vietnam To Afghanistan, Gabe Mora

History Theses

the misinformation about Post-traumatic stress disorder (PTSD) in American society has lead to the stigmatization and discrimination of veterans since the war in Vietnam. PTSD was not a formal diagnosis until 1980, resulting in negative public perception of veterans suffering with this mental illness. Even today as research and information about the disorder has become increasingly available to the public, veterans of the Iraq and Afghanistan wars are facing the same discrimination's as the veterans of Vietnam during their transitions back to civilian life.


Prefrontal Neurons Of Opposite Spatial Preference Display Distinct Target Selection Dynamics., Therese Lennert, Julio C Martinez-Trujillo May 2013

Prefrontal Neurons Of Opposite Spatial Preference Display Distinct Target Selection Dynamics., Therese Lennert, Julio C Martinez-Trujillo

Brain and Mind Institute Researchers' Publications

Neurons in the primate dorsolateral prefrontal cortex (dlPFC) of one hemisphere are selective for the location of attended targets in both visual hemifields. Whether dlPFC neurons with selectivity for opposite hemifields directly compete with each other for target selection or instead play distinct roles during the allocation of attention remains unclear. We explored this issue by recording neuronal responses in the right dlPFC of two macaques while they allocated attention to a target in one hemifield and ignored a distracter on the opposite side. Forty-nine percent of the recorded neurons were target location selective. Neurons selective for contralateral targets (58%) …


Everyday Confrontation Of Discrimination: The Well-Being Costs And Benefits To Women Over Time., Mindi D. Foster Jan 2013

Everyday Confrontation Of Discrimination: The Well-Being Costs And Benefits To Women Over Time., Mindi D. Foster

Psychology Faculty Publications

Taking action against discrimination has positive consequences for well-being (e.g., Cocking & Drury, 2004) but most of this research has focused on collective actions and has used methodologies assessing one point in time. This study therefore used a diary methodology to examine how women’s everyday confrontations of discrimination would affect measures of subjective and psychological well-being, and how these relationships would change over time. In a 28-day online diary study, women indicated their daily experience of discrimination, described their response, and completed measures of well-being. Results showed that at the beginning of the study, using indirect confrontation predicted greater well-being …


A Health Needs Assessment Of Arab-Americans In The Washington, Dc Area, Reem N. Ghoneim, Amita N. Vyas Mar 2012

A Health Needs Assessment Of Arab-Americans In The Washington, Dc Area, Reem N. Ghoneim, Amita N. Vyas

GW Research Days 2012 and Earlier

Although Arab-Americans often face various health challenges due to the stress associated with immigration, cultural conflict in the U.S., and limited knowledge of the complex U.S. health system, there is a paucity of research examining health risks and behaviors among this ethnic group. This cross-sectional study assessed the health needs among Arabs living in the Washington, DC metropolitan area. Participants were recruited to take the survey online, reporting on health care access and utilization, risk behaviors, and health status. It also measured for associations between reported depression, discrimination, acculturation, and health. Quantitative analysis showed correlations between age and current tobacco …


Distinct Patterns Of Functional And Effective Connectivity Between Perirhinal Cortex And Other Cortical Regions In Recognition Memory And Perceptual Discrimination., Edward B O'Neil, Andrea B Protzner, Cornelia Mccormick, D Adam Mclean, Jordan Poppenk, Anthony D Cate, Stefan Köhler Jan 2012

Distinct Patterns Of Functional And Effective Connectivity Between Perirhinal Cortex And Other Cortical Regions In Recognition Memory And Perceptual Discrimination., Edward B O'Neil, Andrea B Protzner, Cornelia Mccormick, D Adam Mclean, Jordan Poppenk, Anthony D Cate, Stefan Köhler

Brain and Mind Institute Researchers' Publications

Traditionally, the medial temporal lobe (MTL) is thought to be dedicated to declarative memory. Recent evidence challenges this view, suggesting that perirhinal cortex (PrC), which interfaces the MTL with the ventral visual pathway, supports highly integrated object representations in recognition memory and perceptual discrimination. Even with comparable representational demands, perceptual and memory tasks differ in numerous task demands and the subjective experience they evoke. Here, we tested whether such differences are reflected in distinct patterns of connectivity between PrC and other cortical regions, including differential involvement of prefrontal control processes. We examined functional magnetic resonance imaging data for closely matched …


Discriminating Famous From Fictional Names Based On Lifetime Experience: Evidence In Support Of A Signal-Detection Model Based On Finite Mixture Distributions., Ben Bowles, Iain M Harlow, Melissa M Meeking, Stefan Köhler Jan 2012

Discriminating Famous From Fictional Names Based On Lifetime Experience: Evidence In Support Of A Signal-Detection Model Based On Finite Mixture Distributions., Ben Bowles, Iain M Harlow, Melissa M Meeking, Stefan Köhler

Brain and Mind Institute Researchers' Publications

It is widely accepted that signal-detection mechanisms contribute to item-recognition memory decisions that involve discriminations between targets and lures based on a controlled laboratory study episode. Here, the authors employed mathematical modeling of receiver operating characteristics (ROC) to determine whether and how a signal-detection mechanism contributes to discriminations between moderately famous and fictional names based on lifetime experience. Unique to fame judgments is a lack of control over participants' previous exposure to the stimuli deemed "targets" by the experimenter; specifically, if they pertain to moderately famous individuals, participants may have had no prior exposure to a substantial proportion of the …


Specific Contributions Of Ventromedial, Anterior Cingulate, And Lateral Prefrontal Cortex For Attentional Selection And Stimulus Valuation., Daniel Kaping, Martin Vinck, R Matthew Hutchison, Stefan Everling, Thilo Womelsdorf Dec 2011

Specific Contributions Of Ventromedial, Anterior Cingulate, And Lateral Prefrontal Cortex For Attentional Selection And Stimulus Valuation., Daniel Kaping, Martin Vinck, R Matthew Hutchison, Stefan Everling, Thilo Womelsdorf

Brain and Mind Institute Researchers' Publications

Attentional control ensures that neuronal processes prioritize the most relevant stimulus in a given environment. Controlling which stimulus is attended thus originates from neurons encoding the relevance of stimuli, i.e. their expected value, in hand with neurons encoding contextual information about stimulus locations, features, and rules that guide the conditional allocation of attention. Here, we examined how these distinct processes are encoded and integrated in macaque prefrontal cortex (PFC) by mapping their functional topographies at the time of attentional stimulus selection. We find confined clusters of neurons in ventromedial PFC (vmPFC) that predominantly convey stimulus valuation information during attention shifts. …


Perirhinal Cortex Contributes To Accuracy In Recognition Memory And Perceptual Discriminations., Edward B O'Neil, Anthony D Cate, Stefan Köhler Jul 2009

Perirhinal Cortex Contributes To Accuracy In Recognition Memory And Perceptual Discriminations., Edward B O'Neil, Anthony D Cate, Stefan Köhler

Brain and Mind Institute Researchers' Publications

The prevailing view of the medial temporal lobe (MTL) holds that its structures are dedicated to long-term declarative memory. Recent evidence challenges this position, suggesting that perirhinal cortex (PRc) in the MTL may also play a role in perceptual discriminations of stimuli with substantial visual feature overlap. Relevant neuropsychological findings in humans have been inconclusive, likely because studies have relied on patients with large and variable MTL lesions. Here, we conducted a functional magnetic resonance imaging study in healthy individuals to determine whether PRc shows a performance-related involvement in perceptual oddball judgments that is comparable to its established role in …


Perceptual Functions Of Perirhinal Cortex In Rats: Zero-Delay Object Recognition And Simultaneous Oddity Discriminations., Susan J Bartko, Boyer D Winters, Rosemary A Cowell, Lisa M Saksida, Timothy J Bussey Mar 2007

Perceptual Functions Of Perirhinal Cortex In Rats: Zero-Delay Object Recognition And Simultaneous Oddity Discriminations., Susan J Bartko, Boyer D Winters, Rosemary A Cowell, Lisa M Saksida, Timothy J Bussey

Brain and Mind Institute Researchers' Publications

The perirhinal cortex (PRh) is widely accepted as having an important role in object recognition memory in humans and animals. Contrary to claims that PRh mediates declarative memory exclusively, previous evidence suggests that PRh has a role in the perceptual processing of complex objects. In the present study, we conducted an examination of the possible role of PRh in perceptual function in rats. We examined whether bilateral excitotoxic lesions of PRh or PPRh (perirhinal plus postrhinal cortices) in the rat would cause deficits in a zero-delay object-recognition task and a simultaneous oddity discrimination task. Both of these tasks measured spontaneous …


Discrimination Of Computer-Graphic Stimuli By Mice: A Method For The Behavioral Characterization Of Transgenic And Gene-Knockout Models., T J Bussey, L M Saksida, L A Rothblat Aug 2001

Discrimination Of Computer-Graphic Stimuli By Mice: A Method For The Behavioral Characterization Of Transgenic And Gene-Knockout Models., T J Bussey, L M Saksida, L A Rothblat

Brain and Mind Institute Researchers' Publications

An automated method is described for the behavioral testing of mice in an apparatus that allows computer-graphic stimulus material to be presented. Mice responded to these stimuli by making a nose-poke toward a computer monitor that was equipped with a touchscreen attachment for detecting responses. It was found that C57BL/6 mice were able to solve single-pair visual discriminations as well as 3-pair concurrent visual discriminations. The finding that mice are capable of complex visual discriminations introduces the possibility of testing mice on nonspatial tasks that are similar to those used with rats, monkeys, and humans. Furthermore, the method seems particularly …