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Full-Text Articles in Medicine and Health Sciences
The Effect Of Gaba A Antagonism On Locomotor Activity And Dopamine Release In The Mouse Caudate Putamen Following Acute Toluene Inhalation: An In-Vivo Microdialysis Study, Sean Callan
Wayne State University Theses
Toluene is ubiquitous solvent commonly inhaled recreationally. Despite its frequency of misuse, there is little understanding of how toluene acts within the brain. To examine this, this master's thesis examined the impact of acutely inhaled toluene on dopamine (DA) release in the mouse CPu in vivo using microdialysis techniques. Toluene inhalation produced dose-dependent increases in DA levels as well as changes in locomotor activity. These effects were potentiated by pre-treatment with the GABAA antagonist bicuculline via reverse microdialysis delivery. These results suggest that the DA dynamics of toluene abuse are related to toluene's previously explored effects on the GABA system. …
Dopaminergic Medication Impairs Feedback-Based Stimulus-Response Learning But Not Response Selection In Parkinson's Disease., Andrew Vo, Nole M Hiebert, Ken N Seergobin, Stephanie Solcz, Allison Partridge, Penny A Macdonald
Dopaminergic Medication Impairs Feedback-Based Stimulus-Response Learning But Not Response Selection In Parkinson's Disease., Andrew Vo, Nole M Hiebert, Ken N Seergobin, Stephanie Solcz, Allison Partridge, Penny A Macdonald
Brain and Mind Institute Researchers' Publications
Cognitive dysfunction is a feature of Parkinson's Disease (PD). Some cognitive functions are impaired by dopaminergic medications prescribed to address the movement symptoms that typify PD. Learning appears to be the cognitive function most frequently worsened by dopaminergic therapy. However, this result could reflect either impairments in learning (i.e., acquisition of associations among stimuli, responses, and outcomes) or deficits in performance based on learning (e.g., selecting responses). We sought to clarify the specific effects of dopaminergic medication on (a) stimulus-response association learning from outcome feedback and (b) response selection based on learning, in PD. We tested 28 PD patients on …