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Dose-Response Effects Of Exercise On Mental Health In Community-Dwelling Older Adults: Exploration Of Genetic Moderators, Swathi Gujral, Marcia Burns, Kirk I. Erickson, Dana Rofey, Jeremiah J. Peiffer, Simon M. Laws, Belinda Brown
Dose-Response Effects Of Exercise On Mental Health In Community-Dwelling Older Adults: Exploration Of Genetic Moderators, Swathi Gujral, Marcia Burns, Kirk I. Erickson, Dana Rofey, Jeremiah J. Peiffer, Simon M. Laws, Belinda Brown
Research outputs 2022 to 2026
Background/Objective: (1) Examine the role of exercise intensity on mental health symptoms in a community-based sample of older adults. (2) Explore the moderating role of genetic variation in brain-derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) on the effects of exercise on mental health symptoms. Method: This study is a secondary analysis of a three-arm randomized controlled trial, comparing the effects of 6 months of high-intensity aerobic training vs. moderate-intensity aerobic training vs. a no-contact control group on mental health symptoms assessed using the Depression, Anxiety, and Stress Scale (DASS). The BDNF Val66Met polymorphism and APOE 4 carrier status were …