Medicine and Health Sciences Commons^™

Validation Of A Virtual Auditory Space, And Its Use To Investigate How Pitch And Spatial Cues Contribute To Perceptual Segregation Of Auditory Streams, Nima Zargarnezhad

Electronic Thesis and Dissertation Repository

The human auditory system can decompose complex sound mixtures into distinct perceptual auditory objects through a process (or processes) known as Auditory Scene Analysis. Pitch and spatial cues are among the sound attributes known to influence sequential streaming (Plack 2018). In this project, the fidelity of a virtual acoustic space (the Audio Dome) in reproducing precisely located sound sources with a 9^th-order ambisonics algorithm was validated. The estimated horizontal Minimum Audible Angles aligned with previously reported values (Mills 1958) homogeneously across the space, and a robust low-frequency presentation was identified. Then, the Audio Dome was utilized to test …

Development And Validation Of The Pain Resilience And Optimism Scale (Pros), Wonjin Seo

Electronic Thesis and Dissertation Repository

Numerous self-report questionnaires have been used in pain research to explore patients' experiences. However, these questionnaires often employ negatively worded items that can potentially worsen patients' distress. In response to the emergence of positive psychology, this thesis aimed to develop a new questionnaire that adopts a positive and strengths-focused approach, incorporating resilience, to replace the negative items found in existing tools such as the Pain Catastrophizing Scale (PCS). First, the effectiveness of the Connor-Davidson Resilience Scale (CD-RISC) in measuring resilience following trauma was assessed through a systematic review using the COnsensus-based Standards for the selection of health status Measurement INstruments …

Disordered Eating Behaviours In Adolescents With And Without A Formal Ed Diagnosis: Comparing Individual And Contextual Factors, Eve G. Chapnik

Electronic Thesis and Dissertation Repository

This study explored various psychosocial factors associated with disordered eating in adolescents accessing mental health services across Ontario, Canada. Data were collected using the interRAI Child and Youth Mental Health (ChYMH) assessment tool and participants were categorized into three groups: individuals with diagnosed eating disorders (ED, n=207), disordered eating without a formal ED diagnosis (sub-ED, n=888), and other treatment-seeking youth (non-ED, n=3285). The ED and sub-ED groups did not differ in many ways, presenting with a similarly greater prevalence of mental health issues, and dysfunctional family and peer relationships, in comparison to non-ED youth. However, the ED …

Exploring The Experience Of Disclosing In The Workplace, Jillian Auger

Electronic Thesis and Dissertation Repository

An alarming rate of workplace violence/harassment is observed each year, with negative outcomes that affect the organization (i.e., financial loss) and those directly involved (i.e., job loss, financial strain, fear of being blamed, being labeled a ‘troublemaker’). The literature indicates that, for many victim-survivors, there is little hope for positive outcomes following a disclosure of workplace violence/harassment. In fact, some studies show that negative reactions to disclosure can compound and intensify the impact of violence/harassment on psychological functioning. However, minimal research has been devoted to the experiences of victim-survivors regarding the outcomes of a disclosure. Utilizing virtual semi-structured interviews, the …

Dentate Gyrus Integrity Is Necessary For Behavioral Pattern Separation But Not Statistical Learning, Helena Shizhe Wang, R. Shayna Rosenbaum, Stevenson Baker, Claire Lauzon, Laura Batterink, Stefan Köhler

Brain and Mind Institute Researchers' Publications

Pattern separation, the creation of distinct representations of similar inputs, and statistical learning, the rapid extraction of regularities across multiple inputs, have both been linked to hippocampal processing. It has been proposed that there may be functional differentiation within the hippocampus, such that the trisynaptic pathway (entorhinal cortex > dentate gyrus > CA3 > CA1) supports pattern separation, whereas the monosynaptic pathway (entorhinal cortex > CA1) supports statistical learning. To test this hypothesis, we investigated the behavioral expression of these two processes in BL, an individual with highly selective bilateral lesions in the dentate gyrus that presumably disrupts the trisynaptic pathway. We tested pattern …

Long Term Outcomes After Norse: Treatment With Vagus Nerve Stimulation, Poul H. Espino, Jorge G. Burneo, Gaby Moscol, Teneille Gofton, Keith Macdougall, Ana Suller-Marti

Brain and Mind Institute Researchers' Publications

New-onset refractory status epilepticus (NORSE) is associated with high mortality, therapy resistant epilepsy (TRE) and poor cognitive and functional outcomes. Some patients develop multifocal TRE, for whom surgery with a curative intention, is not an option. In these patients, Vagus Nerve Stimulation (VNS) is performed as a palliative treatment. We report the long-term outcomes regarding seizure frequency, functional and cognitive outcome, and effectiveness of VNS in two patients with TRE as a consequence of NORSE. In the first patient with cryptogenic NORSE, VNS implantation occurred during the acute stage, probably contributing to the cessation of her status epilepticus. However, in …

No Statistical Learning Advantage In Children Over Adults: Evidence From Behaviour And Neural Entrainment., Christine N Moreau, Marc F. Joanisse, Jerrica Mulgrew, Laura J. Batterink

Brain and Mind Institute Researchers' Publications

Explicit recognition measures of statistical learning (SL) suggest that children and adults have similar linguistic SL abilities. However, explicit tasks recruit additional cognitive processes that are not directly relevant for SL and may thus underestimate children's true SL capacities. In contrast, implicit tasks and neural measures of SL should be less influenced by explicit, higher-level cognitive abilities and thus may be better suited to capturing developmental differences in SL. Here, we assessed SL to six minutes of an artificial language in English-speaking children (n = 56, 24 females, M = 9.98 years) and adults (n = 44; 31 females, M …

Role Of The Default-Mode Network During Narrative Integration In Major Depressive Disorder, Darren Ri-Sheng Liang

Electronic Thesis and Dissertation Repository

How brain activity is synchronized across individuals during narrative comprehension has previously been characterized by functional magnetic resonance imaging (fMRI) in healthy and patient populations. To our knowledge, there has been limited investigation as to how it is affected by major depressive disorder (MDD). We addressed this issue with fMRI through examination of inter-subject synchronization in the default mode network (DMN), brain structures which have previously been implicated in MDD pathology. Twenty-two patients with MDD and 20 matched control participants listened to Intact versus Scrambled versions of an auditory narrative; these experimental conditions differed in the degree of temporal integration …

Assessing The Impact Of Lipopolysaccharide On Learning And Memory In Rats, Anahat Luthra

Undergraduate Student Research Internships Conference

The immune system and the central nervous system (CNS) have a bi-direction relationship, modulating one another.⁴ Proinflammatory cytokines released from CNS immune cells have an impact on cognitive processes such as learning and memory.¹ Liposaccharide (LPS), a cell wall component of Gram-negative bacteria, which is used to activate proinflammatory cytokine release has been found to impact learning and memory processes, such as in the anticipatory nausea paradigm (ANP).² Anticipatory nausea and vomiting is that which may occur before a chemotherapy treatment session begins in a patient who has had chemotherapy before. It is caused by triggers like …

The Effects Of The Aromatase Inhibitor, Letrozole, On Lithium Chloride (Licl)-Induced Conditioned Disgust Behaviour (Anticipatory Nausea) In Male Rats, Vangel Matic

Undergraduate Student Research Internships Conference

Anticipatory Nausea (AN) is a form of classical conditioning in which the effects of a nausea-inducing toxin become associated with a specific environmental context. AN is often experienced by individuals receiving chemotherapy treatment, whereby the emetic effects of the chemotherapy agents become associated with the treatment context (i.e. hospital, clinic), such that exposure to the context alone can cause an individual to experience nausea and potentially withdraw from treatment. Chemotherapy-associated AN is suggested to have a higher incidence in females compared to males.

AN can be represented in a rodent model (conditioned disgust) through the occurrence of conditioned gaping behaviour …

Motor Learning By Observing The Movements Of A Computer-Animated, Human-Like Actor And A Non-Limb Observational Video, Mudia Iyayi

Undergraduate Student Research Internships Conference

Our project is looking at the phenomenon of observational motor learning using a two-joint robotic manipulandum (robotic arm). When someone learns a new motor skill (i.e. throwing a football to a wide receiver) the brain must make and map an internal model of the forces required for that movement. The plasticity of the brain in constructing these representations is termed “motor learning” and can occur through physical practice or—for the purposes of our investigation—observation. Previous studies have used videos of human actors learning new skills to drive motor learning in the observer, however, it is not known what components of …

Auditory Sensory Filtering And Development In Children With Autism Spectrum Disorder, Hiruthika Ravi, Ala Seif, Ryan A. Stevenson

Undergraduate Student Research Internships Conference

Sensory filtering is the process of separating and distilling relevant sensory information from irrelevant, which in turn greatly reduces the quantity of sensory information that is fully processed and leads to significant increases in efficiency. Atypical sensory filtering can result in sensory hypo- or hypersensitivity — atypical sensory filtering and hypo/hypersensitivity have been observed in people with autism. Atypical sensory filtering contributes to canonical symptoms in Autism.

Sensory filtering can be measured in a few different ways, one of which is the Acoustic Startle Response (ASR). ASR is a reflexively produced muscular reaction to sudden auditory stimuli.

Our study aims …

The Coping Strategies Of Older Adults With Age Related Vision Loss (Arvl) – A Narrative Account, Zakara J. Stampp

Electronic Thesis and Dissertation Repository

The goal of this study was to share the stories of older adults with age-related vision loss (ARVL) and how they have coped to maintain meaningful occupational engagement. Grounded in a constructivist paradigm, data collection and analysis were guided by the narrative inquiry methodology. The participants consisted of six older adults aged 60 or older, diagnosed with one of the following ARVL conditions: macular degeneration, diabetic retinopathy, and/or glaucoma. Participants were recruited from vision loss non-profit organizations such as the Canadian National Institute for the Blind (CNIB) and the Alliance for Equity of Blind Canadians (AEBC). One older adult was …

Supporting Post-Secondary Implementation Of Recovery-Oriented Practice In A Stepped Care Model, Janis Campbell

The Dissertation in Practice at Western University

Student mental health has been a growing concern for higher education communities for many years. Campuses have been struggling to keep up with the increasing demand for services which has been complicated further by the COVID-19 pandemic. A Stepped Care model (SCM) developed at a Canadian university has been offering new ways of organizing mental health resources based on open access, student choice, and recovery principles. There are diverse definitions of recovery in the literature and are usually based on values such as empowerment, respect, and self-determination. SCMs have been shown to increase access to resources and reduce or eliminate …

Evaluating The Impact Of A Safe Exercise Training Workshop On Knowledge And Self-Efficacy To Manage Dysfunctional Exercise Among Eating Disorders Clinicians At Alsana Eating Disorders Center, Danika A. Quesnel

Electronic Thesis and Dissertation Repository

Engaging in dysfunctional exercise (DEX) is detrimental to eating disorders (EDs) prognosis, although common amongst clients. Though nutritionally supported exercise can improve ED treatment outcomes, without negatively impacting weight restoration, clinicians remain hesitant to address DEX, perhaps due to a lack of information and training. The current study examined the effects of a Safe Exercise at Every Stage (SEES) training on clinician knowledge and self-efficacy in managing DEX in ED treatment. Eating disorders clinicians completed measures before (n = 96) and after (n = 44) SEES training to assess their knowledge and self-efficacy around treating DEX, with a …

An Open Access Resource For Functional Brain Connectivity From Fully Awake Marmosets, David J. Schaeffer, L Martyn Klassen, Yuki Hori, Xiaoguang Tian, Diego Szczupak, Cecil Chern-Chyi Yen, Justine C. Cléry, Kyle M. Gilbert, Joseph S. Gati, Ravi S. Menon, Cirong Liu, Stefan Everling, Afonso C. Silva

Brain and Mind Institute Researchers' Publications

The common marmoset (Callithrix jacchus) is quickly gaining traction as a premier neuroscientific model. However, considerable progress is still needed in understanding the functional and structural organization of the marmoset brain to rival that documented in longstanding preclinical model species, like mice, rats, and Old World primates. To accelerate such progress, we present the Marmoset Functional Brain Connectivity Resource (marmosetbrainconnectome.org), currently consisting of over 70 h of resting-state fMRI (RS-fMRI) data acquired at 500 µm isotropic resolution from 31 fully awake marmosets in a common stereotactic space. Three-dimensional functional connectivity (FC) maps for every cortical and subcortical gray matter voxel …

Seeing Thro The Musical Eye: Santo Daime, Fuke-Shū, 1960s Psychedelia, And The Antipodes Of Musical Experience, Forest Anthony-Muran

Electronic Thesis and Dissertation Repository

This thesis investigates the relationships between altered states of consciousness and the musical experience in religious tradition and practice. A common accompaniment to religious worship and ceremony, music is often used as a way of attempting to capture something of the ineffable and to help bring about a mystical experience. In this thesis, I make use of three contrasting case studies – the Brazilian syncretic religion Santo Daime, the historical branch of Zen Buddhism Fuke-shū, and the psychedelic rock of 1960s counterculture – to paint a portrait of the variety of ways that music has been used in different musical …

The Genetics Of Pain: An Exploration Of Gene-By-Environment Interactions And Their Effects On Pain, Mohamad F. Fakhereddin

Electronic Thesis and Dissertation Repository

The findings presented in this dissertation are part of the bigger SYMBIOME project which aims to use the biopsychosocial model of pain to develop a prognostic clinical phenotype for people that experience musculoskeletal (MSK) trauma. Chapter 2 presents an exploratory analysis to assess the relationships between genetic polymorphisms and pain severity and interference. Early childhood trauma was also explored as a moderator between genetic polymorphisms and pain outcomes. For pain severity, major allele carriers (A/A and G/A) of FKBP5 rs9394314 reported significantly higher scores than minor allele carriers (G/G). Further, major allele carriers who had at least one adverse childhood …

A Neural Signature Of Regularity In Sound Is Reduced In Older Adults, Björn Herrmann, Burkhard Maess, Ingrid S. Johnsrude

Brain and Mind Institute Researchers' Publications

Sensitivity to repetitions in sound amplitude and frequency is crucial for sound perception. As with other aspects of sound processing, sensitivity to such patterns may change with age, and may help explain some age-related changes in hearing such as segregating speech from background sound. We recorded magnetoencephalography to characterize differences in the processing of sound patterns between younger and older adults. We presented tone sequences that either contained a pattern (made of a repeated set of tones) or did not contain a pattern. We show that auditory cortex in older, compared to younger, adults is hyperresponsive to sound onsets, but …

Completing The Puzzle: Why Studies In Non-Human Primates Are Needed To Better Understand The Effects Of Non-Invasive Brain Stimulation, Sebastian J. Lehmann, Brian D. Corneil

Brain and Mind Institute Researchers' Publications

Brain stimulation is a core method in neuroscience. Numerous non-invasive brain stimulation (NIBS) techniques are currently in use in basic and clinical research, and recent advances promise the ability to non-invasively access deep brain structures. While encouraging, there is a surprising gap in our understanding of precisely how NIBS perturbs neural activity throughout an interconnected network, and how such perturbed neural activity ultimately links to behaviour. In this review, we will consider why non-human primate (NHP) models of NIBS are ideally situated to address this gap in knowledge, and why the oculomotor network that moves our line of sight offers …

Learning Words Without Trying: Daily Second Language Podcasts Support Word Form Learning In Adults, Elise Alexander, Stephen C. Van Hedger, Laura Batterink

Brain and Mind Institute Researchers' Publications

Spoken language contains overlapping patterns across different levels, from syllables to words to phrases. The discovery of these structures may be partially supported by statistical learning (SL), the unguided, automatic extraction of regularities from the environment through passive exposure. SL supports word learning in artificial language experiments, but few studies have examined whether it scales up to support natural language learning in adult second language learners. Here, adult English speakers (n = 70) listened to daily podcasts in either Italian or English for two weeks while going about their normal routines. To measure word knowledge, participants provided familiarity ratings of …

Early Protein Intake Predicts Functional Connectivity And Neurocognition In Preterm Born Children, Emma G. Duerden, Benjamin Thompson, Tanya Poppe, Jane Alsweiler, Greg Gamble, Yannan Jiang, Myra Leung, Anna C. Tottman, Trecia Wouldes, Steven P. Miller, Jane E. Harding, Jane M. Alsweiler, Janene B. Biggs, Coila Bevan, Joanna M. Black, Frank H. Bloomfield, Kelly Fredell, Greg D. Gamble, Jane E. Harding, Sabine Huth, Yannan Jiang, Christine Kevan, Myra Leung, Geraint Phillips, Tanya Poppe, Jennifer A. Rogers, Heather Stewart, Benjamin S. Thompson

Brain and Mind Institute Researchers' Publications

© 2021, The Author(s). Nutritional intake can promote early neonatal brain development in very preterm born neonates (< 32 weeks’ gestation). In a group of 7-year-old very preterm born children followed since birth, we examined whether early nutrient intake in the first weeks of life would be associated with long-term brain function and neurocognitive skills at school age. Children underwent resting-state functional MRI (fMRI), intelligence testing (Wechsler Intelligence Scale for Children, 5th Ed) and visual-motor processing (Beery-Buktenica, 5th Ed) at 7 years. Relationships were assessed between neonatal macronutrient intakes, functional connectivity strength between thalamic and default mode networks (DMN), and neuro-cognitive function using multivariable regression. Greater functional connectivity strength between thalamic networks and DMN was associated with greater intake of protein in the first week (β = 0.17; 95% CI 0.11, 0.23, p < 0.001) but lower intakes of fat (β = − 0.06; 95% CI − 0.09, − 0.02, p = 0.001) and carbohydrates (β = − 0.03; 95% CI − 0.04, − 0.01, p = 0.003). Connectivity strength was also associated with protein intake during the first month (β = 0.22; 95% CI 0.06, 0.37, p = 0.006). Importantly, greater thalamic-DMN connectivity strength was associated with higher processing speed indices (β = 26.9; 95% CI 4.21, 49.49, p = 0.02) and visual processing scores (β = 9.03; 95% CI 2.27, 15.79, p = 0.009). Optimizing early protein intake may contribute to promoting long-term brain health in preterm-born children.

The Development, Short-Term Efficacy, And Pilot Implementation Of An E-Learning Course In Physical Activity And Sedentary Behaviour For Pre-Service Early Childhood Educators, Brianne Bruijns

Electronic Thesis and Dissertation Repository

The overarching purpose of this dissertation was to develop an e-Learning course in physical activity and sedentary behaviour and test its short-term efficacy and implementation among pre- and in-service early childhood educators (ECEs). The Delphi approach was adopted for Study 1, wherein a panel of international experts in physical activity and sedentary behaviour suggested topics for the course and, together with a panel of ECE experts, rated their importance. Study 2 employed a pre-post design to explore the changes in pre- and in-service ECEs’ physical activity and sedentary behaviour-related knowledge, self-efficacy, behavioural intention, and perceived behavioural control following course completion. …

Musical Instrument Familiarity Affects Statistical Learning Of Tone Sequences., Stephen C Van Hedger, Ingrid Johnsrude, Laura J Batterink

Brain and Mind Institute Researchers' Publications

Most listeners have an implicit understanding of the rules that govern how music unfolds over time. This knowledge is acquired in part through statistical learning, a robust learning mechanism that allows individuals to extract regularities from the environment. However, it is presently unclear how this prior musical knowledge might facilitate or interfere with the learning of novel tone sequences that do not conform to familiar musical rules. In the present experiment, participants listened to novel, statistically structured tone sequences composed of pitch intervals not typically found in Western music. Between participants, the tone sequences either had the timbre of artificial, …

Family Functioning As A Moderator In The Relation Between Perceived Stress And Psychotic-Like Experiences Among Adolescents During Covid-19, Zhipeng Wu, Zhulin Zou, Feiwen Wang, Zhibiao Xiang, Mengran Zhu, Yicheng Long, Haojuan Tao, Lena Palaniyappan, Zhening Liu

Brain and Mind Institute Researchers' Publications

Background: The COVID-19 pandemic has increased psychological stress among adolescents, and the relation between perceived stress (PS) and psychotic-like experiences (PLEs) has been well-established. However, little is known about the role of family functioning (FF) in this relation, especially when adolescents experienced the extended lockdown period with family members. Methods: A total of 4807 adolescents completed this retrospective paper-and-pencil survey after school reopening between May 14th and June 6th, 2020 in Hunan Province, China. We measured PS with the Perceived stress scale (PSS-10), PLEs with the eight positive items from Community Assessment of Psychic Experiences (CAPE-8), and FF with the …

Exploring The Role(S) Of Trait Emotional Intelligence & Personality In Help-Seeking Behaviour Among Undergraduate Students, Nikola Cuvalo

Electronic Thesis and Dissertation Repository

Trait emotional intelligence (EI) and the Big Five personality factors represent promising constructs in the individual differences literature that have been investigated in relation to help-seeking behaviour. This quantitative work explores the relationship between individual differences in trait EI, personality, and attitudes toward – as well as future intentions to engage in – help-seeking behaviour among undergraduate students at Western University. Stepwise regression modelling was used to determine which dimensions of personality and trait EI best predicted help-seeking outcomes and whether attitudes toward help-seeking predicted intentions to seek help from university-provided mental health sources. Resultsindicated that several individual facets of …

Investigating The Role Of Targeted Memory Reactivation In Sleep Spindle Production, Justin W. Hopper

Electronic Thesis and Dissertation Repository

In ‘targeted memory reactivation’ (TMR) paradigms, information learned during wakefulness is paired with a cue, and reactivated during sleep by presenting that same cue. TMR improves memory. In a prior study (Antony et al., 2012), participants learned two melodies. One melody was cued during a nap, and performance was better than for the uncued melody. The current study reanalyzed these data to characterize sleep spindle density during TMR cue-periods relative to non-cued periods, and whether spindle density correlated with performance. During TMR stimulation, spindle density was significantly higher than during non-stimulation in four time windows. Compared to the non-TMR group, …

Regional Brain And Spinal Cord Volume Loss In Spinocerebellar Ataxia Type 3, Jennifer Faber, Tamara Schaprian, Koyak Berkan, Kathrin Reetz, Marcondes Cavalcante França, Thiago Junqueira Ribeiro De Rezende, Jiang Hong, Weihua Liao, Bart Van De Warrenburg, Judith Van Gaalen, Alexandra Durr, Fanny Mochel, Paola Giunti, Hector Garcia-Moreno, Ludger Schoels, Holger Hengel, Matthis Synofzik, Benjamin Bender, Gulin Oz, James Joers, Jereon J. De Vries, Jun Suk Kang, Dagmar Timmann-Braun, Heike Jacobi, Jon Infante, Richard Joules, Sandro Romanzetti, Jorn Diedrichsen, Matthias Schmid, Robin Wolz, Thomas Klockgether

Brain and Mind Institute Researchers' Publications

Background: Given that new therapeutic options for spinocerebellar ataxias are on the horizon, there is a need for markers that reflect disease-related alterations, in particular, in the preataxic stage, in which clinical scales are lacking sensitivity. Objective: The objective of this study was to quantify regional brain volumes and upper cervical spinal cord areas in spinocerebellar ataxia type 3 in vivo across the entire time course of the disease. Methods: We applied a brain segmentation approach that included a lobular subsegmentation of the cerebellum to magnetic resonance images of 210 ataxic and 48 preataxic spinocerebellar ataxia type 3 mutation carriers …

Functional Organization Of Frontoparietal Cortex In The Marmoset Investigated With Awake Resting-State Fmri, Yuki Hori, Justine C. Cléry, David J. Schaeffer, Ravi S. Menon, Stefan Everling

Brain and Mind Institute Researchers' Publications

Frontoparietal networks contribute to complex cognitive functions in humans and macaques, such as working memory, attention, task-switching, response suppression, grasping, reaching, and eye movement control. However, there has been no comprehensive examination of the functional organization of frontoparietal networks using functional magnetic resonance imaging in the New World common marmoset monkey (Callithrix jacchus), which is now widely recognized as a powerful nonhuman primate experimental animal. In this study, we employed hierarchical clustering of interareal blood oxygen level-dependent signals to investigate the hypothesis that the organization of the frontoparietal cortex in the marmoset follows the organizational principles of the macaque frontoparietal …

Sustained Neural Activity Correlates With Rapid Perceptual Learning Of Auditory Patterns, Björn Herrmann, Kurdo Araz, Ingrid S. Johnsrude

Brain and Mind Institute Researchers' Publications

Repeating structures forming regular patterns are common in sounds. Learning such patterns may enable accurate perceptual organization. In five experiments, we investigated the behavioral and neural signatures of rapid perceptual learning of regular sound patterns. We show that recurring (compared to novel) patterns are detected more quickly and increase sensitivity to pattern deviations and to the temporal order of pattern onset relative to a visual stimulus. Sustained neural activity reflected perceptual learning in two ways. Firstly, sustained activity increased earlier for recurring than novel patterns when participants attended to sounds, but not when they ignored them; this earlier increase mirrored …