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Locomotion And Conditioned Place Preference Produced By Acute Intravenous Amphetamine: Role Of Dopamine Receptors And Individual Differences In Amphetamine Self-Administration, M. T. Bardo, J. M. Valone, Rick A. Bevins

Department of Psychology: Faculty Publications

Although previous studies have shown that dopamine (DA) antagonists block amphetamine reward, these studies have utilized animal models that involve repeated exposures to amphetamine. The present investigation examined the effect of DA antagonists on single-trial conditioned place preference (CPP) produced by acute intravenous (IV) amphetamine in rats. In the first experiment, rats were prepared with a jugular catheter and then received an acute IV injection of amphetamine (0.1–3 mg/kg) paired with one compartment of a CPP apparatus. Relative to sham controls (no IV catheter), amphetamine produced a dose-dependent increase in locomotor activity and CPP. Two further experiments demonstrated that both …