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Full-Text Articles in Medicine and Health Sciences
Memory-Related Frontal Brainwaves Predict Transition To Mild Cognitive Impairment In Healthy Older Individuals Five Years Before Diagnosis, Yang Jiang, Juan Li, Frederick A. Schmitt, Gregory A. Jicha, Nancy B. Munro, Xiaopeng Zhao, Charles D. Smith, Richard J. Kryscio, Erin L. Abner
Memory-Related Frontal Brainwaves Predict Transition To Mild Cognitive Impairment In Healthy Older Individuals Five Years Before Diagnosis, Yang Jiang, Juan Li, Frederick A. Schmitt, Gregory A. Jicha, Nancy B. Munro, Xiaopeng Zhao, Charles D. Smith, Richard J. Kryscio, Erin L. Abner
Behavioral Science Faculty Publications
BACKGROUND: Early prognosis of high-risk older adults for amnestic mild cognitive impairment (aMCI), using noninvasive and sensitive neuromarkers, is key for early prevention of Alzheimer's disease. We have developed individualized measures in electrophysiological brain signals during working memory that distinguish patients with aMCI from age-matched cognitively intact older individuals.
OBJECTIVE: Here we test longitudinally the prognosis of the baseline neuromarkers for aMCI risk. We hypothesized that the older individuals diagnosed with incident aMCI already have aMCI-like brain signatures years before diagnosis.
METHODS: Electroencephalogram (EEG) and memory performance were recorded during a working memory task at baseline. The individualized baseline neuromarkers, …
Low Arousal Positive Emotional Stimuli Attenuate Aberrant Working Memory Processing In Persons With Mild Cognitive Impairment, Lucas S. Broster, Shonna L. Jenkins, Sarah D. Holmes, Gregory A. Jicha, Yang Jiang
Low Arousal Positive Emotional Stimuli Attenuate Aberrant Working Memory Processing In Persons With Mild Cognitive Impairment, Lucas S. Broster, Shonna L. Jenkins, Sarah D. Holmes, Gregory A. Jicha, Yang Jiang
Behavioral Science Faculty Publications
Emotional enhancement effects on memory have been reported to mitigate the pathophysiology of Alzheimer’s disease (AD). However, relative to their manifestation in persons without pathologic aging, these effects may be reduced in magnitude or even deleterious, especially in tasks that more closely model ecologic memory performance. Based upon a synthesis of such reports, we hypothesized that in persons with AD low arousal positive stimuli would evoke relatively intact emotional enhancement effects, but that high arousal negative stimuli would evoke disordered emotional enhancement effects. To assess this, participants with and without mild cognitive impairment (MCI) presumed to be due to AD …
A Cognitive Electrophysiological Signature Differentiates Amnestic Mild Cognitive Impairment From Normal Aging, Juan Li, Lucas S. Broster, Gregory A. Jicha, Nancy B. Munro, Frederick A. Schmitt, Erin L. Abner, Richard J. Kryscio, Charles D. Smith, Yang Jiang
A Cognitive Electrophysiological Signature Differentiates Amnestic Mild Cognitive Impairment From Normal Aging, Juan Li, Lucas S. Broster, Gregory A. Jicha, Nancy B. Munro, Frederick A. Schmitt, Erin L. Abner, Richard J. Kryscio, Charles D. Smith, Yang Jiang
Behavioral Science Faculty Publications
Background: Noninvasive and effective biomarkers for early detection of amnestic mild cognitive impairment (aMCI) before measurable changes in behavioral performance remain scarce. Cognitive event-related potentials (ERPs) measure synchronized synaptic neural activity associated with a cognitive event. Loss of synapses is a hallmark of the neuropathology of early Alzheimer’s disease (AD). In the present study, we tested the hypothesis that ERP responses during working memory retrieval discriminate aMCI from cognitively normal controls (NC) matched in age and education.
Methods: Eighteen NC, 17 subjects with aMCI, and 13 subjects with AD performed a delayed match-to-sample task specially designed not only to be …
The Development Of Attention Systems And Working Memory In Infancy, Greg D. Reynolds, Alexandra C. Romano
The Development Of Attention Systems And Working Memory In Infancy, Greg D. Reynolds, Alexandra C. Romano
Psychology Publications and Other Works
In this article, we review research and theory on the development of attention and working memory in infancy using a developmental cognitive neuroscience framework. We begin with a review of studies examining the influence of attention on neural and behavioral correlates of an earlier developing and closely related form of memory (i.e., recognition memory). Findings from studies measuring attention utilizing looking measures, heart rate, and event-related potentials (ERPs) indicate significant developmental change in sustained and selective attention across the infancy period. For example, infants show gains in the magnitude of the attention related response and spend a greater proportion of …
A Critical Evaluation Of Selective Attention Measures, Hannah K. Wilson
A Critical Evaluation Of Selective Attention Measures, Hannah K. Wilson
Mahurin Honors College Capstone Experience/Thesis Projects
Selective attention is comprised of two simultaneous processes—the inhibition of distractors and the focus of attention on target stimuli; yet, many existing selective attention measures only measure one aspect of selective attention. This leads to a high possibility of Type I errors as high interference control or high working memory capacity may be mistaken for high selective attention. This paper proposes several criteria for high construct validity and external validity in selective attention measures.
Concerning construct validity, the test must allow participants to exercise selective attention, adequately measure the level of attention to the distractor stimuli, and adequately measure level …
The Role Of Executive Function In Children's Source Monitoring With Varying Retrieval Strategies, Kim P. Roberts, Becky Earhart
The Role Of Executive Function In Children's Source Monitoring With Varying Retrieval Strategies, Kim P. Roberts, Becky Earhart
Psychology Faculty Publications
Previous research on the relationship between executive function and source monitoring in young children has been inconclusive, with studies finding conflicting results about whether working memory and inhibitory control are related to source-monitoring ability. In this study, the role of working memory and inhibitory control in recognition memory and source monitoring with two different retrieval strategies were examined. Children (N = 263) aged 4–8 participated in science activities with two sources. They were later given a recognition and source-monitoring test, and completed measures of working memory and inhibitory control. During the source-monitoring test, half of the participants were asked …
Tms-Induced Neural Noise In Sensory Cortex Interferes With Short-Term Memory Storage In Prefrontal Cortex, Tyler D. Bancroft, Jeremy Hogeveen, William E. Hockley, Philip Servos
Tms-Induced Neural Noise In Sensory Cortex Interferes With Short-Term Memory Storage In Prefrontal Cortex, Tyler D. Bancroft, Jeremy Hogeveen, William E. Hockley, Philip Servos
Psychology Faculty Publications
In a previous study, Harris et al. (2002) found disruption of vibrotactile short-term memory after applying single-pulse transcranial magnetic stimulation (TMS) to primary somatosensory cortex (SI) early in the maintenance period, and suggested that this demonstrated a role for SI in vibrotactile memory storage. While such a role is compatible with recent suggestions that sensory cortex is the storage substrate for working memory, it stands in contrast to a relatively large body of evidence from human EEG and single-cell recording in primates that instead points to prefrontal cortex as the storage substrate for vibrotactile memory. In the present study, we …
Does Emotional Memory Enhancement Assist The Memory-Impaired?, Lucas S. Broster, Lee X. Blonder, Yang Jiang
Does Emotional Memory Enhancement Assist The Memory-Impaired?, Lucas S. Broster, Lee X. Blonder, Yang Jiang
Behavioral Science Faculty Publications
We review recent work on emotional memory enhancement in older adults and patients with mild cognitive impairment (MCI) or Alzheimer dementia (AD) and evaluate the viability of incorporating emotional components into cognitive rehabilitation for these groups. First, we identify converging evidence regarding the effects of emotional valence on working memory in healthy aging. Second, we introduce work that suggests a more complex role for emotional memory enhancement in aging and identify a model capable of unifying disparate research findings. Third, we survey the neuroimaging literature for evidence of a special role for the amygdala in MCI and early AD in …
Toward A Formal Theory Of Flexible Spatial Behavior: Geometric Category Biases Generalize Across Pointing And Verbal Response Types, John P. Spencer, Vanessa R. Simmering, Anne R. Schutte
Toward A Formal Theory Of Flexible Spatial Behavior: Geometric Category Biases Generalize Across Pointing And Verbal Response Types, John P. Spencer, Vanessa R. Simmering, Anne R. Schutte
Department of Psychology: Faculty Publications
Three experiments tested whether geometric biases—-biases away from perceived reference axes—-reported in spatial recall tasks with pointing responses generalized to a recognition task that required a verbal response. Seven-year-olds and adults remembered the location of a dot within a rectangle and then either reproduced its location or verbally selected a matching choice dot from a set of colored options. Results demonstrated that geometric biases generalized to verbal responses; however, the spatial span of the choice set influenced performance as well. These data suggest that the same spatial memory process gives rise to both response types in this task. Simulations of …