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Full-Text Articles in Medicine and Health Sciences
Machine Learning Based Classification Of Deep Brain Stimulation Outcomes In A Rat Model Of Binge Eating Using Ventral Striatal Oscillations, Wilder Doucette, Lucas Dwiel, Jared E. Boyce, Amanda A. Simon, Jibran Y. Khokhar, Alan I. Green
Machine Learning Based Classification Of Deep Brain Stimulation Outcomes In A Rat Model Of Binge Eating Using Ventral Striatal Oscillations, Wilder Doucette, Lucas Dwiel, Jared E. Boyce, Amanda A. Simon, Jibran Y. Khokhar, Alan I. Green
Dartmouth Scholarship
Neuromodulation-based interventions continue to be evaluated across an array of appetitive disorders but broader implementation of these approaches remains limited due to variable treatment outcomes. We hypothesize that individual variation in treatment outcomes may be linked to differences in the networks underlying these disorders. Here, Sprague-Dawley rats received deep brain stimulation separately within each nucleus accumbens (NAc) sub-region (core and shell) using a within-animal crossover design in a rat model of binge eating. Significant reductions in binge size were observed with stimulation of either target but with significant variation in effectiveness across individuals. When features of local field potentials (LFPs) …
Independent And Interactive Associations Of Negative Affect, Restraint, And Impulsivity In Relation To Binge Eating Among Women, Tyler B. Mason, Kathryn E. Smith, Jason M. Lavender, Robin J. Lewis
Independent And Interactive Associations Of Negative Affect, Restraint, And Impulsivity In Relation To Binge Eating Among Women, Tyler B. Mason, Kathryn E. Smith, Jason M. Lavender, Robin J. Lewis
Psychology Faculty Publications
There is growing recognition that impulsivity may serve as an underlying risk factor for binge eating. In addition, the association of impulsivity with binge eating may be moderated by other affective and cognitive risk factors. This study examined independent and interactive associations of negative affect, dietary restraint, and facets of impulsivity with binge eating. A diverse sample of 566 undergraduate women completed online questionnaires of study variables. Results revealed a three-way interaction of negative affect, dietary restraint, and attentional impulsivity in relation to binge eating. Women who were high on each of these three variables reported the greatest levels of …