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Effects Of Chlorpromazine On Feeding And Wheel Running On Rats With Acute Wheel Access, Graham Gregory Parfeniuk

Theses and Dissertations (Comprehensive)

Anorexia Nervosa (AN) is characterized by a self-imposed starvation and is often accompanied by excessive exercise that results in severe malnutrition and sometimes death. Behavioural and pharmacological treatments of AN need to be improved. In rats, acute 3 h daytime wheel access suppresses ad lib feeding over the subsequent night relative to no wheel controls, a phenomenon that has been suggested as an animal model of AN. This acute wheel induced feeding suppression (WIFS), can be induced reliably when rats are given limited wheel access exposure during the light cycle (Lattanzio & Eikelboom, 2003). The acute WIFS is useful because …