Medicine and Health Sciences Commons^™

Dietary Probiotic Supplement Attenuates Methamphetamine-Induced Conditioned Place Preference In Female Sprague-Dawley Rats, Kristen Powell

Masters Theses

Substance use disorders (SUD) represent a global public health crisis with limited effective treatment options. Recent findings implicate the gut microbiome and gut/brain axis in the pathophysiology of SUDs. Several preclinical studies have established that psychostimulants alter gut microbiome composition, but no published studies have assessed behavioral effects of dietary probiotic supplements on drug-induced behavioral changes. This study utilized rodent conditioned place preference (CPP) as a behavioral index of conditioned drug reward to determine if a dietary probiotic supplement alters the behavioral effects of (+)-methamphetamine (METH). Fifty-four adult female Sprague-Dawley rats were randomly assigned to receive either a standard rodent …

Benzofuran Derivatives Substitute For The Discriminative Stimulus Effects Of 3,4methylenedioxymethamphetamine (Mdma) In Male Sprague-Dawley Rats, Candace Johnson

Masters Theses

4-Methylenedioxymethamphetamine (MDMA) is currently under evaluation in phase III clinical trials as medication-assisted therapy for post-traumatic stress disorder (PTSD) and is expected to be approved by the FDA for clinical use in the near future. MDMA is also a popular abused substance with risks for cardiovascular toxicity and neurotoxicity, particularly when misused at higher doses. Characterization of the behavioral and neurochemical effects of novel psychoactive substances is an essential step in the development of safer alternative therapeutic agents. Drug discrimination is a preclinical behavioral assay with pharmacological specificity for characterizing in vivo drug actions in the central nervous system. This …

Effects Of Low Dose Mixtures Of 3,4-Methylenedioxypyrovalerone And Cocaine On Locomotor Activity And Brain Monoamine Content In Sprague-Dawley Rats, Robert J. Kohler

Masters Theses

Synthetic cathinones, known as “bath salts” on the illicit drug market, pose a significant and growing public health concern. 3,4-Methylenedioxypyrovalerone (MDPV), one of several popular constituents of the illicit bath salts, produces similar pharmacological actions to cocaine, albeit with greater potency. The present study sought to characterize behavioral and neurochemical effects of repeated exposure to MDPV alone and in combination with cocaine. Male Sprague-Dawley rats were randomly assigned to one of four treatments: 1 mg/kg MDPV, 5 mg/kg cocaine, 1 mg/kg MDPV + 5 mg/kg cocaine, or saline. Locomotor activity was assessed for one hour immediately before and one hour …

Sleep Hygiene Practices: A Cross Cultural Survey Of Sleeping And Dreaming In College Students, Ivan Noe Martinez Salazar

Masters Theses

There is consensus that a sizeable percentage of people in most developed countries do not obtain adequate amounts or quality of sleep. These disruptions in sleep, when chronic and severe, can lead to psychological, behavioral and health consequences. The focus on behavioral and contextual factors that impact sleep has been termed “sleep hygiene”. An on-line anonymous survey collected sociodemographic information, as well as self-reports on sleep, sleep hygiene practices and dreaming across two cultural groups (English & Spanish speaking responders). A total of 204 participants (majority of them college and graduate students) answered the survey. Both cultural groups, English and …

The Acute Effects Of Cocaine In Pigeons Performing Under A Progressive-Ratio Schedule, Claudia Ann Jones

Masters Theses

Although the progressive-ratio (PR) schedule has been used frequently to quantify the reinforcing effectiveness of self-administered drugs, it has seldom been used to examine the effects of drugs on food-maintained behavior and has never been used to evaluate the effects of cocaine on such behavior. In the present study, the effects of acute administrations of cocaine were evaluated in pigeons responding under a PR schedule of food delivery. Overall, cocaine produced a dose-dependent effect on food-maintained behavior. In general, acute administrations of cocaine at 0.56 to 3.2 mg/kg increased breaking points, whereas doses above 5.6 mg/kg decreased breaking points. Low …

The Effects Of Music Video Violence On The Aggression Level Of Emotionally Disturbed Adolescents, Kathleen Jo Young

Masters Theses

The purpose of this study was to investigate the effects of violent music videos on aggressive behavior in psychiatrically hospitalized adolescents. Associations between male and female responses were investigated as well as responses between high-aggressive and low-aggressive subjects.

Subjects were 30 in-patient emotionally disturbed adolescents, 13 to 17 years of age. Subjects served as their own controls. Treatment consisted of the viewing of a violent video with violent lyrics, a violent video without violent lyrics, and a non-violent video. Aggression was measured prior to the treatment with a 23 True-False questionnaire completed by subjects and Behavior Rating Forms completed by …

The Effect Of Discrimination Training On Salt And Sugar Taste Thresholds Of Preschool Children, Susan M. Castine

Masters Theses

Using a single-subject A-B-C-D design, this study examined NaCl and sucrose taste thresholds in water, tomato juice, and milk with four 4-year-old children. Taste thresholds were determined by presenting several concentrations of an adulterant (i.e. NaCl, sucrose) in each vehicle, in blocks of ten trials. Subjects evaluated each taste sample by pressing one of two levers (Yes/No response). Detection threshold was defined as the level at which there was 50% correct responding. During Baseline, subjects received no feedback regarding the accuracy of their response. During the differential reinforcement phase, subjects received reinforcement following each correct response. Results suggested that detection …

The Problem Of Reductionism In Theories Of Hemispheric Specialization And Recovery Of Functions, Grant Jackson Butterbaugh

Masters Theses

A selective review of functional and anatomical hemispheric asymmetries in humans confirms the doctrine of hemispheric specialization. However, the post-insult phenomenon of recovery of functions challenges theories that posit too strict a correspondence between anatomical structures and functions. Follow-up studies on hemispherectomized and hemidecorticated patients, who later recovered language, support a hypothesis of hemispheric redundancy, rather than "invariant" hemispheric specialization for language. Thus, through an evolutionary selection process, the brain may have developed as two potentially similar organs. Neuropsychological research on recovery phenomena is criticized as neglecting environmental contributions to recovery. Several models of hemispheric specialization are compared with recovery …

The Detection Of Behavioral Effects In The F(Sub)1(/Sub) Generation Of Mice Treated During Spermatogenesis With Cyclophosphamide, Procarbazine Or Mitomycin C, Anthony Michael Podraza

Masters Theses

Five CF₁ male mice were injected with 300 mg Procarbazine, 2 mg of Mitomycin C, 40 mg of Cyclophosphamide per kg body weight or saline control. Each male was mated to two untreated females 1-2 and 8-9 weeks after treatment, allowing for the evaluation of treatment upon spermatooza and spermatogonium, respectively. Offspring were evaluated through observations of reproduction. Dominant lethal effect was seen in the 8-9 week Cyclophosphamide, 1-2 and 8-9 week Procarbazine groups. Decreased weights were seen in all three treatment groups from the two mating times. In the water escape test, the 1-2 week Mitomycin C, 8-9 …

A Comparison Of Personality Self-Descriptions Using A Structured Personality Inventory And Open-Ended Personality Questionnaire And Critical Incident Survey, Birda Lee Walker

Masters Theses

The purpose of this study is to determine whether individuals presented with a well defined list of adjectives demonstrate suggestibility, i.e., would rate themselves differently on the Adjective Check List (ACL), versus the open-ended test such as the Clinical Analysis Questionnaire (CAQ) or Critical Incident Survey (CIS).

The participants in this study were 36 adult volunteers drawn from three different populations: 12 prison inmates, 12 undergraduates from a university, and 12 outpatients of a mental health clinic. The participants were administered the three tests in individual and group sessions.

The prisoners did not fake “bad" or "good" more so on …