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University of Nebraska - Lincoln
Conditioned avoidance response; drug memory; haloperidol; interoceptive drug state; olanzapine; rat; risperidone
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Avoidance-Suppressing Effect Of Antipsychotic Drugs Is Progressively Potentiated After Repeated Administration: An Interoceptive Drug State Mechanism, Alexa Lucille Mead, Ming Li
Avoidance-Suppressing Effect Of Antipsychotic Drugs Is Progressively Potentiated After Repeated Administration: An Interoceptive Drug State Mechanism, Alexa Lucille Mead, Ming Li
Department of Psychology: Faculty Publications
Antipsychotic drugs selectively suppress conditioned avoidance response. Using a two-way active avoidance response paradigm, we examined the role of drug-induced interoceptive state in the mediation of avoidance-suppressive effect. In Experiment 1, we found that rats intermittently treated with olanzapine (OLZ) (1.0 mg/kg, s.c.) or haloperidol (0.03 mg/kg, s.c.) on the 1st day of a 3-day cycle for seven cycles exhibited a progressive across-session decline in avoidance responding, despite the fact that they exhibited a comparable high level of avoidance responding on the 3rd day of each cycle during the drug-free retraining session. In Experiments 2 and 3, rats that were …