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Psychiatry and Psychology

University of Nebraska - Lincoln

Series

2009

Amphetamine; Phencyclidine; Antipsychotic drug; Anxiolytic drug; Hyperlocomotor activity; Schizophrenia; Animal models of schizophrenia

Articles 1 - 1 of 1

Full-Text Articles in Medicine and Health Sciences

Repeated Antipsychotic Treatment Progressively Potentiates Inhibition On Phencyclidine-Induced Hyperlocomotion, But Attenuates Inhibition On Amphetamine-Induced Hyperlocomotion: Relevance To Animal Models Of Antipsychotic Drugs, Tao Sun, Gang Hu, Ming Li Jan 2009

Repeated Antipsychotic Treatment Progressively Potentiates Inhibition On Phencyclidine-Induced Hyperlocomotion, But Attenuates Inhibition On Amphetamine-Induced Hyperlocomotion: Relevance To Animal Models Of Antipsychotic Drugs, Tao Sun, Gang Hu, Ming Li

Department of Psychology: Faculty Publications

Clinical obervations indicate that antipsychotic action starts early and increases in magnitude with repeated treatment. Animal models that faithfully capture this time course of action are few. Inhibition of hyperlocomotion induced by amphetamine or phencyclidine has been widely used as a screening tool for the antipsychotic activity of a drug. We thus investigated whether repeated antipsychotic treatment could produce an early-onset and progressively increased antagonistic effect on amphetamine or phencyclidine-induced hyperlocomotion as a way of assessing the validity of such models in capturing time course of antipsychotic action. One each of the five consecutive test days, different groups of rats …